Neuroprotective effect of chitosan nanoparticle gene delivery system grafted with acteoside (ACT) in Parkinson's disease models

被引：1

作者：

Yongyong Xue ^{[1
]}

Na Wang ^{[1
]}

Zhi Zeng ^{[2
,3
]}

Jinpeng Huang ^{[2
,3
]}

Zhiming Xiang ^{[3
,4
]}

YanQing Guan ^{[1
,2
,3
]}

机构：

[1] MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, South China Normal University

[2] School of Life Science, South China Normal University

[3] South China Normal University-Panyu Central Hospital Joint Laboratory of Translational Medical Research, Panyu Central Hospital

[4] Department of Radiology, Guangzhou Panyu Center Hospital

来源：

JournalofMaterialsScience&Technology | 2020年 / 43卷 / 08期

关键词：

Parkinson’s disease; Chitosan nanoparticles; Acteoside; Gene therapy; pDNA;

D O I：

暂无

中图分类号：

R742.5 [震颤麻痹综合征];

学科分类号：

1002 ;

摘要：

Developing new drugs to treat Parkinson's disease efficiently is challenging. Here we report that chitosan nanoparticles(APPDNs) could serve as novel candidates for the design of anti-PD drugs. In this study, we investigated the effects of chitosan poly ethyleneglycol-poly lactic acid(PEG-PLA) nanoparticles conjugated with nerve growth factor(NGF), acteoside(ACT) and plasmid DNA(p DNA) for PD therapy using in vitro and in vivo models. Using PD cell models, we demonstrated that APPDN had good neuroprotective effects. More significantly, experiments using mouse PD models demonstrated that APPDNs could ameliorate the behavioral disorders of sick mice. Immunohistochemical and western blot(WB) analyses demonstrated that APPDNs could significantly reverse dopaminergic(DA) neuron loss in the substantia nigra and striatum of sick mice. This study opens up a novel avenue to develop anti-PD drugs.

引用

页码：197 / 207

页数：11

共 22 条

[1]

Specific optical rotation for the identification of the locus of solubilization of chiral molecules in achiral micelles[J] . Vijay Raghavan,Cody L. Covington,Prasad L. Polavarapu.Journal of Molecular Spectroscopy . 2018

[2]

A synthetic snake-venom-based tripeptide （Glu-Val-Trp） protects PC12 cells from MPP + toxicity by activating the NGF-signaling pathway[J] . Carolina P. Bernardes,Neife A.G. Santos,Flavia M. Sisti,Rafaela Scalco Ferreira,Norival A. Santos-Filho,Adélia C.O. Cintra,Eduardo M. Cilli,Suely V. Sampaio,Antonio C. Santos.Peptides . 2018

[3]

Design and evaluation of galactosylated chitosan/graphene oxide nanoparticles as a drug delivery system[J] . Chen Wang,Zhiqiang Zhang,Binbin Chen,Liuqiong Gu,Yuan Li,Shuwei Yu.Journal of Colloid And Interface Science . 2018

[4]

Progress in brain targeting drug delivery system by nasal route[J] . Abdur Rauf Khan,Mengrui Liu,Muhammad Wasim Khan,Guangxi Zhai.Journal of Controlled Release . 2017

[5]

Targeted gene delivery of polyethyleneimine-grafted chitosan with RGD dendrimer peptide in α v β 3 integrin-overexpressing tumor cells[J] . Young-Min Kim,Seong-Cheol Park,Mi-Kyeong Jang.Carbohydrate Polymers . 2017

[6]

Temperature-responsive nanogel multilayers of poly（N-vinylcaprolactam） for topical drug delivery[J] . Oleksandra Zavgorodnya,Carlos A. Carmona-Moran,Veronika Kozlovskaya,Fei Liu,Timothy M. Wick,Eugenia Kharlampieva.Journal of Colloid And Interface Science . 2017

[7]

Curcumin-loaded dual pH- and thermo-responsive magnetic microcarriers based on pectin maleate for drug delivery[J] . Elizangela A.M.S. Almeida,Ismael C. Bellettini,Francielle P. Garcia,Maroanne T. Farinácio,Celso V. Nakamura,Adley F. Rubira,Alessandro F. Martins,Edvani C. Muniz.Carbohydrate Polymers . 2017

[8]

Abiotic and biotic environmental degradation of the bioplastic polymer poly（lactic acid）: A review[J] . Mehlika Karamanlioglu,Richard Preziosi,Geoffrey D. Robson.Polymer Degradation and Stability . 2017

[9] An updated review of Parkinson's disease genetics and clinicopathological correlations [J].

Ferreira, M. ;

Massano, J. .

ACTA NEUROLOGICA SCANDINAVICA, 2017, 135 (03) :273-284

[10]

New advances in the biodegradation of Poly（lactic） acid[J] . Xiang Qi,Yiwei Ren,Xingzu Wang.International Biodeterioration ＆ Biodegradation . 2017

← 1 2 3 →