Effect of the cyclic stretch and role of related signal pathway on the osteogenic differentiation of MC3T3-E1 cells

<正>Mechanical strain stimulation is one of the important factors to regulate bone metabolism,maintain bone mass and bone structure.In the process of osteoblasts response to the mechanical strain stimulation,the signal transduction pathways were activated by mechanical stimulation Extracellular signal regulated kinase 1/2(ERK1/2)and Nuclear factor kappa B(NF-κB)signal pathways are both important in the process of signal transduction in osteoblasts.They played an important role in differentiation of osteogenic progenitor cells.Therefore in this research we cultured MC3T3-E1 osteoblasts,and established the vitro model of the mechanical strain stimulation,to observe the differentiation of MC3T3-E1 osteoblastic cells and investigate the interac-