Effects of adenosine triphosphate concentration on motor force regulation during skeletal muscle contraction

被引：0

作者：

J.Wei ^{[1
]}

C.Dong ^{[1
]}

B.Chen ^{[1
]}

机构：

[1] Department of Engineering Mechanics,Zhejiang University

来源：

Acta Mechanica Sinica | 2017年 / 02期

基金：

中国国家自然科学基金;

关键词：

Motor force regulation; ATP; Muscle contraction; Myosin;

D O I：

暂无

中图分类号：

R318.01 [生物力学];

学科分类号：

0831 ;

摘要：

We employ a mechanical model of sarcomere to quantitatively investigate how adenosine triphosphate(ATP)concentration affects motor force regulation during skeletal muscle contraction. Our simulation indicates that there can be negative cross-bridges resisting contraction within the sarcomere and higher ATP concentration would decrease the resistance force from negative cross-bridges by promoting their timely detachment. It is revealed that the motor force is well regulated only when ATP concentration is above a certain level. These predictions may provide insights into the role of ATP in regulating coordination among multiple motors.

引用

页码：243 / 249

页数：7

共 7 条

[1] Motor Force Homeostasis in Skeletal Muscle Contraction [J].