The role of the Notch signaling pathway in liver injury and repair

被引：0
作者：
Yue Zhen-Sheng
Ruan Bai
Duan Juan-Li
Han Hua
Wang Lin
机构：
[1] State Key Laboratory of Cancer Biology
[2] Fourth Military Medical University
[3] Xi’an
[4] Department of Hepatobiliary Surgery
[5] China
[6] Xijing Hospital
[7] Shaanxi Province
[8] School of Aerospace Medicine
[9] Aerospace Clinical Medical Center
[10] Department of Biochemistry and Molecular Biology
来源：
生物组学研究杂志（英文） | 2018年 / 1卷 / 02期
关键词：
hepatocytes; liver injury; liver sinusoidal endothelial cells; macrophages; Notch signaling;
D O I：
暂无
中图分类号：
R575 [肝及胆疾病];
学科分类号：
1002 ; 100201 ;
摘要：
This review aims to compile recent advances regarding the significance of Notch signaling in different types of intrahepatic cells during liver injury and repair. The functions of Notch signaling in regulating cell development, fate decisions, and organ homeostasis have been widely acknowledged. Notch is also expressed and activated in hepatocytes, macrophages, liver sinusoidal endothelial cells, endothelial progenitor cells, and hepatic progenitor cells during the process of development, injury, inflammation, fibrosis, and carcinoma. During acute/chronic liver injury, Notch interacts with many signaling pathways that are involved in liver repair. Recent research, including ours, has confirmed the crucial role of Notch signaling in modulating the function of diverse intrahepatic cells during liver injury and reconstruction. Thus, Notch signaling may serve as a potential therapeutic target for liver diseases.
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收藏
页码：95 / 104
页数：10
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