Olfactory Dysfunction in Parkinson's Disease Patients with the LRRK2 G2385R Variant

Olfactory dysfunction has been reported in Parkinson’s disease(PD) patients carrying the LRRK2G2019 S variant in Caucasians but rarely in those with die LRRK2 G2385 R variant.In this study,we performed genotyping for the LRRK2 G2385 R variant in PD patients recruited from the Movement Disorder Clinic of Xuanwu Hospital in Beijing and in healthy controls randomly selected from the Beijing Longitudinal Study on Aging cohort.The "five-odor olfactory detection array",an olfactory threshold test,was used to assess olfactory function.One hundred and eighty-six participants were enrolled,comprising 43 PD patients without(iPD) and 25with(LRRK2-PD) the LRRK2 G2385 R variant,and 118 healthy controls.Our results showed mat the threshold of olfactory identification was significantly worse in PD patients than in controls,but not significantly different between me iPD and LRRK2-PD groups.These findings suggested that although olfactory function in LRRK2-PD patients is impaired,it is similar to that in iPD patients.