Precise regulation of intermembrane spacing with DNA nanojunctions for enhanced T-cell receptor triggering

被引：0

作者：

Lele Sun ^{[1
]}

Zhuang Liu ^{[2
]}

机构：

[1] School of Life Sciences,Shanghai University

[2] Institute of Functional Nano & Soft Materials (FUNSOM),Jiangsu Key Lab Carbon Based Functional Materials and Devices,Soochow University

来源：

Science China(Chemistry) | 2023年 / 08期

关键词：

D O I：

暂无

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

<正>It is well known that adaptive immunity involving T cells plays a crucial role in combating many diseases.T-cell activation is initiated by the engagement of T-cell receptors(TCRs) to peptide-loaded major histocompatibility complexes(p MHCs) on antigen-presenting cells(APCs),which triggers a cascade of signaling events that ultimately lead to T-cell activation [1].

引用

页码：2157 / 2159

页数：3

共 5 条

[1]

Sun Lele,Shen Fengyun,Xu Jun,Han Xiao,Fan Chunhai,Liu Zhuang.DNA-Edited Ligand Positioning on Red Blood Cells to Enable Optimized T Cell Activation for Adoptive Immunotherapy[J].Angewandte Chemie (International ed. in English),2020

[2] Initiation of T cell signaling by CD45 segregation at 'close contacts' [J].