Synthesis, characterization and biological applications of novel Schiff bases of 2-(trifluoromethoxy) aniline

被引:2
|
作者
Thierry Youmbi Fonkui [1 ]
Monisola Itohan Ikhile [2 ]
Freddy Munyololo Muganza [3 ]
Marthe Carine Djuidje Fotsing [2 ]
Charmaine Arderne [4 ]
Xavier Siwe-Noundou [5 ]
Rui Werner Macedo Krause [5 ]
Derek Tantoh Ndinteh [2 ]
Patrick Berka Njobeh [1 ]
机构
[1] Department of Biotechnology and Food Technology, University of Johannesburg
[2] Department of Applied Chemistry, University of Johannesburg
[3] Department of Chemistry, Sefako Makgatho Health Sciences University  4. Department of Chemistry,University of Johannesburg  5. Department of Che
关键词
Synthesis; Biological activity; Schiff bases; Antimicrobial; 2-(Trifluoromethoxy) aniline;
D O I
暂无
中图分类号
TQ460.1 [基础理论];
学科分类号
1007 ;
摘要
A series of five new Schiff bases(1–5) were synthesized by reacting 2-(trifluoromethoxy) aniline with different aromatic aldehydes. The Schiff base compounds were characterized by spectroscopic and analytical methods. Crystal structure of one new compound was also reported. The pharmacological properties, including antibacterial(14 bacterial species), antifungal(7 strains), antimalarial, anti-trypanosomal and anti-HIV activities of the compounds, were investigated. Cytotoxicity of the tested compounds was evaluated against human cervix adernocarcinoma cells(He La). Bacterial minimum inhibitory concentration(MIC) results by broth microdilution method showed that Bacillus subtilis, Enterococcus faecalis, Staphylococcus aureus, Staphylococcus epidermidis, Proteus vulgaris, Klebsiella oxytoc and Klebsiella pneumonia were more sensitive in the presence of tested compounds with an MIC value of 15.6 μg/m L. All the tested compounds showed good to moderate activity against fungi. The sensitivity of Aspergillus fumigatus was higher than other strains with a minimum cell death concentration(MFC) of 15.6 μg/m L. Compound 1 showed greater antimalarial and anti-trypanosomal properties with very low to no cytotoxic effects against He La cells as compared with compound 5, while other compounds exhibited poor activity. Compounds 1–5 demonstrated good activity against HIV type-1. These Schiff base compounds could be used as good antimicrobial agents.
引用
收藏
页码:307 / 323
页数:17
相关论文
共 50 条
  • [1] Synthesis and Crystal Structures of Two Schiff Bases of 2-(Methylthio)aniline with Halogenated Salicylaldehydes
    Christopher G. Hamaker
    Oksana S. Maryashina
    Dana K. Daley
    Andrew L. Wadler
    Journal of Chemical Crystallography, 2010, 40 : 34 - 39
  • [2] Synthesis and Crystal Structures of Two Schiff Bases of 2-(Methylthio) aniline with Halogenated Salicylaldehydes
    Hamaker, Christopher G.
    Maryashina, Oksana S.
    Daley, Dana K.
    Wadler, Andrew L.
    JOURNAL OF CHEMICAL CRYSTALLOGRAPHY, 2010, 40 (01) : 34 - 39
  • [3] Synthesis, Characterization and Biological Activity of Schiff Bases
    Ashraf, Muhammad Aqeel
    Mahmood, Karamat
    Wajid, Abdul
    Maah, Mohd Jamil
    Yusoff, Ismail
    CHEMISTRY AND CHEMICAL PROCESS, 2011, : 1 - 7
  • [4] Synthesis, characterization, and biological properties of novel Schiff bases containing pentafluorophenyl hydrazine
    Hamurcu, Fatma
    JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 2023, 37 (12)
  • [5] Synthesis and characterization of novel porphyrin Schiff bases
    Wang, Lei
    Feng, Yaqing
    Xue, Jinqiang
    Li, Yukun
    JOURNAL OF THE SERBIAN CHEMICAL SOCIETY, 2008, 73 (01) : 1 - 6
  • [6] Electronic structure of Schiff bases - 2-(salicylideneamino) phenol, 2-(salicylideneamino) aniline and 2-(salicylideneamino)benzenethiol
    Kumagai, K
    Hasegawa, M
    Okubo, J
    Hoshi, T
    NIPPON KAGAKU KAISHI, 2001, (09) : 507 - 515
  • [7] Studies on Synthesis, Characterization and Biological Activities of Novel Schiff Bases from amino acridone
    Habeeb, Maryam Fawzi
    Sheat, Attalla M.
    EGYPTIAN JOURNAL OF CHEMISTRY, 2023, 66 (06): : 225 - 234
  • [8] Overview on Synthesis, Reactions, Applications, and Biological Activities of Schiff Bases
    Mukhtar, Shorouk S.
    Hassan, Ashraf S.
    Morsy, Nesrin M.
    Hafez, Taghrid S.
    Hassaneen, Hamdi M.
    Saleh, Fatma M.
    EGYPTIAN JOURNAL OF CHEMISTRY, 2021, 64 (11): : 6541 - 6554
  • [9] Synthesis and optical characterization of novel carbazole Schiff bases
    Cicek, Baki
    Calisir, Umit
    Tavasli, Mustafa
    Tulek, Remziye
    Teke, Ali
    JOURNAL OF MOLECULAR STRUCTURE, 2018, 1153 : 42 - 47
  • [10] Synthesis, characterization, and biological activity of Schiff bases metal complexes
    Zoubi, Wail Al
    Al-Hamdani, Abbas Ali Salih
    Ahmed, Susan Duraid
    Ko, Young Gun
    JOURNAL OF PHYSICAL ORGANIC CHEMISTRY, 2018, 31 (02)