Aberrant DNA Methylation in Human Cancers

被引：0

作者：

黎文 ^{[1
]}

陈碧峰 ^{[2
]}

机构：

[1] Editorial Department of Journal of Clinical Surgery,Hubei Medical Association

[2] School of Biomedical Sciences,Faculty of Medicine,The Chinese University of Hong Kong

来源：

Current Medical Science | 2013年 / 06期

关键词：

epigenetics; aberrant DNA methylation; human cancers; treatment;

D O I：

暂无

中图分类号：

R730.2 [肿瘤病理学、病因学];

学科分类号：

100214 ;

摘要：

DNA methylation,one of the best-characterized epigenetic modifications,plays essential roles in diseases,including human cancers.In recent years,our understanding on DNA methylation with human cancers has made significant progress,which was facilitated by stunning development in the analysis of the human methylome of multiple cancer types.In this review,recent developments in the characterization of aberrant DNA methylation involved in human cancers development were discussed with special emphasis on the mechanisms of aberrant DNA methylation in human cancers.We also summarize the recent treatment strategy for human cancers with de-methylation drugs.

引用

页码：798 / 804

页数：7

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