Matrine inhibits proliferation of mouse skin fibroblasts induced by platelet-derived growth factor-BB

被引：0

作者：

伍严安

高春芳

王皓

黄超

孔宪涛

机构：

来源：

JournalofMedicalCollegesofPLA | 2001年 / 02期

关键词：

matrine; fibroblast; platelet-derivedgrowthfactor;

D O I：

暂无

中图分类号：

R329.2 [人体细胞学];

学科分类号：

100101 ;

摘要：

Objective:To studythe effectof matrineon proliferationof mouseskinfibroblastsinducedby platelet-derivedgrowthfactor-BB(PDGF-BB).Methods :MouseskinfibroblastswereobtainedfromnewbornI-CRmiceandpropagatedin vitro.Proliferationof cellwasanalyzedby mitochondrialreductionof tetrazoliumsalt MTT andactualcellcount.Re sults:Matrine(50to500μg/ml)causeddose-dependentreductionof serum-stimu-latedcellgrowth.Growthinhibitionwas totallyreversedafterremovalof the drug.Matrinealso inhibited PDGF-BBinducedcellgrowthdose-dependently.Conclusion:Matrineexhibitspotentanti-proliferationeffecton mouseskinfibroblast.Thiseffectappearsto be mediatedby decreaseof PDGF-inducedgrowth.Theseresultssug-gestthatmatrinemighthavepreventiveandtherapeuticimplicationin skinfibrosis.

引用

页码：132 / 134

页数：3