EFFECTS OF DIPSACUS ASPER AND VITAMIN E ON THE SS NEURONS IN THE HIPPOCAMPAL FORMATION OF RAT MODELS OF ALZHEIMER'S DISEASE

Objective To study the effects of Dipsacus Asper and Vitamin E on the SS neurons in the hippocampal formation of rat models of Alzheimer’s Disease (AD). Methods Established rat models of AD by giving water containing AlCl 3, then treating them with Dipsacus Asper and Vitamin E(VE) for three months, observed the changing condition of rats’ memory through behavior tests, and studied changes of SS neurons in hippocampal formation with immunohistochemical ABC method. Results 3 months after treatment, behavior tests showed that rats’ memory was improved and the SS neurons in each region of hippocampal formation were increased, In CA1,CA2,CA3 and dentate gyrus, there were significant differences among treated groups and control group( P <0.05). In addition to the differences of quantity, the shape of SS neurons changed too: cytoplasm was stained strongly and equally, bodies and processes were rather clear.Conclusion Dipsacus Asper and Vitamin E can restore the SS neurons in AD models and SS neurons in hippocampal formation are related to AD’s cause and development.