Preparation of Ternary Lanthanide Complexes with Unsaturated Acid and 1,10-Phenanthroline, and Their Anti-Inflammatory Action

被引:1
|
作者
刘鸿
张惠珍
曾伟
曾正志
机构
[1] A. M. Todd Company
[2] Drug Metabolism (Department
[3] U.S.A.
[4] China
[5] Montgomeryville
[6] ) Merck Research Laboratory
[7] Merck & Co.
[8] Lanzhou University
[9] U.S.A
[10] Pennsylvania
[11] Lanzhou 730000
[12] College of Chemistry and Chemical Engineering
[13] Research and Development
[14] West Point
关键词
unsaturated acid; 1,10-phenanthroline; ternary lanthanide complexes; anti-inflammatory; burn; rare earths;
D O I
暂无
中图分类号
O626 [杂环化合物];
学科分类号
070303 ; 081704 ;
摘要
Four ternary lanthanide complexes with unsaturated acid and 1,10-phenanthroline are prepared in methanol and characterized by elemental analysis, molar conductance, UV, IR, (()1H) NMR and XPS. The results from this paper show that the complexes Ln(phen)(SA)3·2H2O or Ln(phen)(CA)3·H2O (Ln=Ce(Ⅲ), Sm(Ⅲ) and Eu(Ⅲ), (phen=1,10-)phenanthroline, SA=Sorbate and CA=Cinnamate) has better anti-inflammatory effect than cerium nitrate and their gremores are steadier than cerium nitrate gremor. And there is a kind of medicament which can replace the cerium nitrate gremor completely in treating burn.
引用
收藏
页码:46 / 50
页数:5
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