Preparation, Characterization, and in vitro Release of Biodegradable Erythromycin-gelatin Microspheres

被引:0
作者
WANG Fei LIU Pai JIANG Dan LIU Chengbai ZHANG Fengchun and CHEN Xia College of Life Science Jilin University Changchun P R China College of Life Science Beihua University Jilin P R China [1 ,1 ,1 ,1 ,1 ,2 ,1 ,1 ,130021 ,2 ,132013 ]
机构
关键词
In vitro degradation; Gelatin; Erythromycin; Microsphere;
D O I
暂无
中图分类号
TQ465 [抗菌素制造];
学科分类号
100705 ;
摘要
Blank and erythromycin-loaded gelatin microspheres were successfully fabricated via emulsion chemical- crosslinking technique. The surface morphology of the microspheres was characterized by scanning electron microscope(SEM) and optical microscope. The results show that the microspheres were spherical and smooth. The particle average size of erythromycin-loaded microspheres was found to be 20.6 μm, with a high purity of more than 90% and with a good dispersibility. The microspheres could be obtained in a high yield. Erythromycin released from the microspheres was monitored in buffer and artificial body fluid at 37 °C. Average drug content was 27.2%, and erythromycin-loaded gelatin microspheres showed good release profiles with a nearly constant release during 4―8 h in artificial body fluid in vitro degradation studies. These gelatin microspheres are useful for studying and developing various drug-delivery systems.
引用
收藏
页码:196 / 199
页数:4
相关论文
共 50 条
[41]   Nanoencapsulation of Eggplant (Solanum melongena L.) Peel Extract in Electrospun Gelatin Nanofiber: Preparation, Characterization, and In Vitro Release [J].
Elizabeth Estrella-Osuna, Danya ;
Agustin Tapia-Hernandez, Jose ;
Ruiz-Cruz, Saul ;
Marquez-Rios, Enrique ;
de Jesus Ornelas-Paz, Jose ;
Lizette Del-Toro-Sanchez, Carmen ;
Manuel Ocano-Higuera, Victor ;
Rodriguez-Felix, Francisco ;
Isabel Estrada-Alvarado, Maria ;
Alberto Cira-Chavez, Luis .
NANOMATERIALS, 2022, 12 (13)
[42]   Study on Preparation and Analysis of Tea Polyphenols Loaded Gelatin/Chitosan Microspheres [J].
Zhao, Ming-Da ;
Xu, Jian-Mei ;
Xie, Rui-Juan ;
Wang, Jian-Nan .
TEXTILE BIOENGINEERING AND INFORMATICS SYMPOSIUM (TBIS) PROCEEDINGS, 2019, 2019, :149-156
[43]   Preparation and in vitro release profiling of PLGA microspheres containing BSA as a model protein [J].
Dabaghi, Nazanin ;
Seyfoddin, Vahid ;
Toliyat, Tayebeh ;
Ataie, Zahra .
BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2020, 56
[44]   Preparation and in vitro Release Properties of Mercaptopurine Drug-loaded Magnetic Microspheres [J].
Xu Haixing ;
Zhang Yu ;
Niu Xiaoqian ;
Wang Ling ;
Chen Hui ;
Zhang Xi ;
Tang Qiuhan ;
Huang Zhijun ;
Liu Hui ;
Xu Peihu .
JOURNAL OF WUHAN UNIVERSITY OF TECHNOLOGY-MATERIALS SCIENCE EDITION, 2013, 28 (06) :1231-1235
[45]   Fabrication and Characterization of Biodegradable Nanofiber Containing Gelatin [J].
Yun, So Hee ;
Kim, Young-Jin ;
Kwon, Oh Kyoung ;
Choi, Myung-Seok ;
Kim, Young-Jin ;
Kwon, Oh Hyeong .
TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 2008, 5 (4-6) :835-841
[46]   PREPARATION OF BIODEGRADABLE POLY(LACTIC-CO-GLYCOLIC) ACID MICROSPHERES AND THEIR INVITRO RELEASE OF TIMOLOL MALEATE [J].
STURESSON, C ;
CARLFORS, J ;
EDSMAN, K ;
ANDERSSON, M .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1993, 89 (03) :235-244
[47]   PREPARATION AND CHARACTERIZATION OF BIODEGRADABLE THIN FILM GELATIN GRAFTED VINYL ACETATE-METHYLEMETHACRYLATE NANOCOMPOSITE [J].
Fatima, U. ;
Shahid, S. ;
Nadeem, S. .
DIGEST JOURNAL OF NANOMATERIALS AND BIOSTRUCTURES, 2017, 12 (02) :549-554
[48]   Preparation of NLCs-Based Topical Erythromycin Gel: In Vitro Characterization and Antibacterial Assessment [J].
Zafar, Ameeduzzafar ;
Imam, Syed Sarim ;
Yasir, Mohd ;
Alruwaili, Nabil K. ;
Alsaidan, Omar Awad ;
Warsi, Musarrat Husain ;
Ullah, Shehla Nasar Mir Najib ;
Alshehri, Sultan ;
Ghoneim, Mohammed M. .
GELS, 2022, 8 (02)
[49]   Preparation and characterization of magnetic targeted drug controlled-release hydrogel microspheres [J].
Chen, J ;
Yang, LM ;
Liu, YF ;
Ding, GW ;
Pei, Y ;
Li, J ;
Hua, GF ;
Huang, J .
MACROMOLECULAR SYMPOSIA, 2005, 225 :71-80
[50]   Biodegradable polymeric microspheres for nalbuphine prodrug controlled delivery: in vitro characterization and in vivo pharmacokinetic studies [J].
Liu, FI ;
Kuo, JH ;
Sung, KC ;
Hu, OY .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2003, 257 (1-2) :23-31