New insights into the functions and localization of the homeotic gene CDX2 in gastric cancer

被引：0
作者：
Lin-Hai Yan [1 ]
Wei-Yuan Wei [1 ]
Yu-Bo Xie [2 ]
Qiang Xiao [1 ]
机构：
[1] Department of Surgery,The First Affiliated Hospital of Guangxi Medical University
[2] Department of Anesthesiology,The First Affiliated Hospital of Guangxi Medical University
来源：
World Journal of Gastroenterology | 2014年 / 14期
基金：
中国国家自然科学基金;
关键词：
Caudal-related homeobox transcription factor 2; Gastric cancer; Intestinal metaplasia; Apoptosis; Drug resistance;
D O I：
暂无
中图分类号：
R735.2 [胃肿瘤];
学科分类号：
100214 ;
摘要：
Gastric cancer is one of the most frequent cancers,and it ranks the third most common cancer in China.The most recently caudal-related homeobox transcription factor 2(CDX2)is expressed in a large number of human gastrointestinal cancers.In addition,gastric epithelial cell mutations in CDX2 result in tumor promotion,which is characterized by cellular drug resistance and a high proclivity for developing cancer.A series of publications over the past years suggests a mechanism by which CDX2 overexpression results in multidrug resistance.CDX2 appears to forward control regenerating Ⅳand the multidrug resistance 1 expression signaling pathway for regulation of cell drug resistance.
引用
收藏
页码：3960 / 3966
页数：7
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