Storage Stability of Alpha-Lipoic Acid-loaded Lipid Nanoparticles

被引：0
作者：
唐金国 [1 ,2 ]
夏强 [1 ,2 ,3 ]
刘光煜 [1 ,2 ]
机构：
[1] State Key Laboratory of Bioelectronics,Southeast University
[2] Suzhou Key Laboratory of Biomedical Materials and Technology
[3] Suzhou Nanohealth Biotech
来源：
过程工程学报 | 2010年 / 10卷 / 02期
关键词：
alpha-lipoic acid; lipid nanoparticles; storage stability; particle size; particle morphology;
D O I：
暂无
中图分类号：
TB383.1 [];
学科分类号：
摘要：
Alpha-lipoic acid-loaded lipid nanoparticles(ALA-LNs) were prepared by high pressure homogenization method.The influences of storage conditions such as time and temperature on the physical and chemical storage stability of ALA-LNs were studied in details.The stability was evaluated by particle size and polydispersity index,morphology of ALA-LNs,and capacity of ALA loading.The dilution and pH stability of ALA-LNs suspensions were also studied.After three months storage,the mean size of ALA-LNs at 4 and 40 ℃ was increased by 2.68% and 3.62% compared with the original size,respectively.ALA-LNs stored at 40 ℃ had ellipsoid shape and the mean size was about 152 nm(SD=23.6).The loading capacity of ALA at 40 ℃ was much higher than those stored at other two temperatures.The good dilution and pH stability were also demonstrated.The sample had good fluidity even at 4 ℃.
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页码：332 / 338
页数：7
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  • [1] 咪喹莫特纳米结构脂质载体的可控制备及表征
    周华锋
    马全红
    丁艺
    夏强
    旷英姿
    郝晓帧
    顾宁
    [J]. 过程工程学报, 2006, (04) : 598 - 602
  • [2] 硫辛酸脂质纳米粒的制备工艺研究[J]. 夏强,唐金国,徐弟,徐峰.纳米科技. 2008 (06)
  • [3] α-Lipoic acid suppresses 6-hydroxydopamine-induced ROS generation and apoptosis through the stimulation of glutathione synthesis but not by the expression of heme oxygenase-1[J] . Hirofumi Fujita,Masahiko Shiosaka,Tetsuya Ogino,Yuya Okimura,Toshihiko Utsumi,Eisuke F. Sato,Reiko Akagi,Masayasu Inoue,Kozo Utsumi,Junzo Sasaki.Brain Research . 2008
  • [4] Targeting lipoic acid to mitochondria: Synthesis and characterization of a triphenylphosphonium-conjugated α-lipoyl derivative[J] . Stephanie E. Brown,Meredith F. Ross,Alejandra Sanjuan-Pla,Abdul-Rahman B. Manas,Robin A.J. Smith,Michael P. Murphy.Free Radical Biology and Medicine . 2007 (12)
  • [5] Nanostructured lipid carriers (NLC) in cosmetic dermal products
    Mueller, R. H.
    Petersen, R. D.
    Hornmoss, A.
    Pardeike, J.
    [J]. ADVANCED DRUG DELIVERY REVIEWS, 2007, 59 (06) : 522 - 530
  • [6] A novel approach based on lipid nanoparticles (SLN?) for topical delivery of α-lipoic acid[J] . E. B. Souto,R. H. Müller,S. Gohla.Journal of Microencapsulation . 2005 (6)
  • [7] Copper toxicity, oxidative stress, and antioxidant nutrients[J] . Lisa M. Gaetke,Ching Kuang Chow.Toxicology . 2003 (1)
  • [8] Nanostructured lipid matrices for improved microencapsulation of drugs[J] . R.H Müller,M Radtke,S.A Wissing.International Journal of Pharmaceutics . 2002 (1)
  • [9] Solid lipid nanoparticles as carrier for sunscreens: in vitro release and in vivo skin penetration[J] . S.A. Wissing,R.H. Müller.Journal of Controlled Release . 2002 (3)
  • [10] Investigation on the viscoelastic properties of lipid based colloidal drug carriers
    Lippacher, A
    Müller, RH
    Mäder, K
    [J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2000, 196 (02) : 227 - 230
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