Analysis of colonic autofluorescence spectra using multivariate curve resolution alternating least squares

被引：0
|
作者：
刘丽娜 [1 ]
杨常顺 [2 ]
李伟华 [2 ]
李步洪 [1 ]
谢树森 [1 ]
机构：
[1] Key Laboratory of OptoElectronic Science and Technology for Medicine of Ministry of Education,Fujian Provincial Key Laboratory for Photonics Technology, Fujian Normal University
[2] Department of Surgical Oncology, Fujian Provincial Hospital
来源：
ChineseOpticsLetters | 2014年 / 12卷 / 05期
关键词：
ALS; MCR; Analysis of colonic autofluorescence spectra using multivariate curve resolution alternating least squares;
D O I：
暂无
中图分类号：
O433 [光谱学];
学科分类号：
0703 ; 070302 ;
摘要：
Autofluorescence(AF) spectra of colonic normal and adenocarcinoma tissues are measured under excitation of 337 nm and analyzed by multivariate curve resolution alternating least squares(MCR-ALS) method using non-negativity constraint. Collagen, nicotinamide adenine dinucleotide hydrate(NADH) and elastin are identified as the main contributing biomedical components. Fisher’s discrminant anlysis(FDA) on the concentration profiles of the principle components(PCs) shows acceptable sensitivity, specificty and accuracy for discrminanting the adenocarcinoma tissues from the normal tissues. MCR-ALS is a powerful tool for characterzing the spectra profiles of the main biochemical components in neoplasm transformation.
引用
收藏
页码：61 / 64
页数：4
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