Copper-mediated O-arylation of lactols with aryl boronic acids

被引：0
|
作者：
Jing-Jing Sui [1 ,2 ]
De-Cai Xiong [2 ,3 ]
Xin-Shan Ye [1 ,2 ]
机构：
[1] National Research Center for Carbohydrate Synthesis, Jiangxi Normal University
[2] State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University
[3] State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
来源：
Chinese Chemical Letters | 2019年 / 30卷 / 08期
基金：
中国国家自然科学基金; 国家重点研发计划;
关键词：
Phenolic glycoside; O-Arylation; Lactol; Aryl boronic acid;
D O I：
暂无
中图分类号：
O629.13 [糖苷];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient and novel methodology to access phenolic glycosides has been established by using coppermediated coupling reaction of aryl boronic acids with hemiacetals. The reaction takes place normally in the presence of Cu（OAc）;（1.0 equiv.） and pyridine（2.0 equiv.） at 40℃. This protocol distinguishes itself by wide substrate scope, operational simplicity and giving rise to a myriad of phenolic glycosides in good to excellent yields.
引用
收藏
页码：1533 / 1537
页数：5
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