Human immunodeficiency virus infection and the liver

被引：1

作者：

Megan Crane ^{[1
,2
]}

David Iser ^{[3
,4
]}

Sharon R Lewin ^{[1
,2
,4
]}

机构：

[1] Department of Medicine,Monash University

[2] Centre for Virology,Burnet Institute 3. Department of Gastroenterology,St Vincent's Hospital 4. Australia Infectious Disease Unit

来源：

World Journal of Hepatology | 2012年 / 4卷 / 03期

基金：

澳大利亚国家健康与医学研究理事会;

关键词：

Human immunodeficiency virus; Liver dis-ease; Low-middle income settings;

D O I：

暂无

中图分类号：

R512.91 [获得性免疫缺陷综合征（AIDS艾滋病）];

学科分类号：

100401 ;

摘要：

Liver disease in human immunodeficiency virus(HIV)-infected individuals encompasses the spectrum from abnormal liver function tests,liver decompensation,with and without evidence of cirrhosis on biopsy,to non-alcoholic liver disease and its more severe form,non-alcoholic steatohepatitis and hepatocellular cancer.HIV can infect multiple cells in the liver,leading to enhanced intrahepatic apoptosis,activation and fibrosis.HIV can also alter gastro-intestinal tract permeability,leading to increased levels of circulating lipopolysaccharide that may have an impact on liver function.This review focuses on recent changes in the epidemiology,pathogenesis and clinical presentation of liver disease in HIV-infected patients,in the absence of co-infection with hepatitis B virus or hepatitis C virus,with a specific focus on issues relevant to low and middle income countries.

引用

页码：91 / 98

页数：8

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