Indoleamine 2,3-dioxygenase: As a potential prognostic marker and immunotherapeutic target for hepatocellular carcinoma

被引：10

作者：

Kashif Asghar ^{[1
]}

Asim Farooq ^{[1
,2
]}

Bilal Zulfiqar ^{[3
]}

Muhammad Usman Rashid ^{[1
]}

机构：

[1] Department of Basic Sciences Research, Shaukat Khanum Memorial Cancer Hospital and Research Centre

[2] Department of Biomedical Engineering and Sciences, School of Mechanical and Manufacturing Engineering, National University of Sciences and Technology

[3] Eskitis Institute for Drug Discovery, Griffith University

来源：

World Journal of Gastroenterology | 2017年 / 23卷 / 13期

关键词：

Hepatocellular carcinoma; Hepatitis C virus; Hepatitis B virus; Indoleamine 2,3-dioxygenase;

D O I：

暂无

中图分类号：

R735.7 [肝肿瘤];

学科分类号：

100214 ;

摘要：

Tumor cells induce an immunosuppressive microen-vironment which leads towards tumor immune escape. Understanding the intricacy of immunomodulation by tumor cells is essential for immunotherapy. Indoleamine 2,3-dioxygenase(IDO) is an immunosuppressive enzyme which mediates tumor immune escape in various cancers including hepatocellular carcinoma(HCC). IDO up-regulation in HCC may lead to recruitment of regulatory T-cells into tumor microenvironment and therefore inhibit local immune responses and promote metastasis. HCC associated fibroblasts stimulate natural killer cells dysfunction through prostaglandin E2 and subsequently IDO promotes favorable condition for tumor metastasis. IDO up-regulation induces immuno-suppression and may enhance the risk of hepatitis C virus and hepatitis B virus induced HCC. Therefore, IDO inhibitors as adjuvant therapeutic agents may have clinical implications in HCC. This review proposes future prospects of IDO not only as a therapeutic target but also as a prognostic marker for HCC.

引用

页码：2286 / 2293

页数：8

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