Antiviral therapies for hepatitis B virus-related hepatocellular carcinoma

被引：0

作者：

Yuan-Qing Zhang ^{[1
]}

Jin-Sheng Guo ^{[1
]}

机构：

[1] Division of Digestive Diseases,Department of Internal Medicine,Zhong Shan Hospital,Shanghai Medical College,Fu Dan University

来源：

World Journal of Gastroenterology | 2015年 / 13期

关键词：

Chronic hepatitis B; Hepatocellular carcinoma; Antiviral therapy;

D O I：

暂无

中图分类号：

R735.7 [肝肿瘤];

学科分类号：

100214 ;

摘要：

Chronic hepatitis B virus(HBV) infection is a critical risk factor for the carcinogenesis and progression of hepatocellular carcinoma(HCC). It promotes HCC development by inducing liver fibrogenesis, genetic and epigenetic alterations, and the expression of active viral-coded proteins. Effective antiviral treatments inhibit the replication of HBV, reduce serum viral load and accelerate hepatitis B e antigen serum conversion. Timely initiation of antiviral treatment is not only essential for preventing the incidence of HCC in chronic hepatitis B patients, but also important for reducing HBV reactivation, improving liver function, reducing or delaying HCC recurrence, and prolonging overall survival of HBV-related HCC patients after curative and palliative therapies. The selection of antiviral drugs, monitoring of indicators such as HBV DNA and hepatitis B surface antigen, and timely rescue treatment when necessary, are essential in antiviral therapies for HBVrelated HCC.

引用

页码：3860 / 3866

页数：7

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