A stereoselective synthesis of the C(3)-C(13) and C(14)-C(24) fragments of macrolactin A

被引：0

作者：

李树坤

徐睿

肖相树

白东鲁

机构：

[1] ShanghaiInstituteofMateriaMedica,ChineseAcademyofSciences,Shanghai,China,ShanghaiInstituteofMateriaMedica,ChineseAcademyofSciences,Shanghai,China,ShanghaiInstituteofMateriaMedica,ChineseAcademyofSciences,Shanghai,China,ShanghaiInstituteofMateriaMedica,Chin

来源：

Chinese Journal of Chemistry | 2000年 / 06期

关键词：

Macrolactin A; antiviral; stereoselective synthesis; Wittig reaction; sulfone alkylation; Julia olefination;

D O I：

暂无

中图分类号：

O621 [有机化学一般性问题];

学科分类号：

070303 ; 081704 ;

摘要：

<正> Synthetic studies towards(he C(3)-C(13)and C(14)-C(24)segments(3,4)of the potent antiviral and antitumor compound macrolactin A(1)are presented.Compound 3 was constructed via a convergent and facile approach,exploiting Wittig olefination to generate the sensitive E,Z-diene moiety.Compound 4 was synthesized from the chiral-pod derived sul-fone 39a via an o-alkylation-desulfonation reaction sequence.Cu(Ⅱ)-catalyzed coupling of a Grignard reagent with an al-lylic bromide and Julia olefination were also investigated for the preparation of compound 4.

引用

页码：910 / 923

页数：14