A Novel Drug Delivery System for Osteosarcoma Chemotherapy

被引：0

作者：

樊东辉

张维颖

机构：

[1] School of Material Science and Engineering Tongji University Shanghai 200092

[2] China

[3] School of Material Science and Engineering Tongji University Shanghai 200092

来源：

Journal of Wuhan University of Technology-Materials Science | 2005年 / S1期

关键词：

drug delivery; osteosarcoma; thermo-responsive hydrogel; chitosan;

D O I：

暂无

中图分类号：

R738.1 [骨骼肿瘤];

学科分类号：

100214 ;

摘要：

A thermo-responsive chitosan hydrogel system (TRCHS) was prepared by chitosan(CS) and β-glycerophosphate(β-GP) to deliver Adriamycin (ADM) locally for curing osteosarcoma. Release property was investigated by release experiments in vitro and results show that it can be applied to local drug release because it is able to release drug at high concentration for 17 days. The treatment effect was studied by injecting intratumorally to osteosarcoma tumors (CRL-1427) implanted subcutaneously on Specific Pathogen-free (SPF) mice. The statistical analytical results show that TRCHS delivering ADM is more efficacious than saline intratumoral injection, which loads the same quantity of ADM, but is less poisonous. Based on the analysis above, this novel biodegradable polymer implant is an effective and safe vehicle for sustained local delivery of ADM, and is supposed to be applied in neoadjuvant chemotherapy for osteosarcoma.

引用

页码：229 / 231

页数：3