GnIH/GPR147和Kisspeptin/GPR54与青春发育启动

被引：4

作者：

李素环

汪永红

机构：

[1] 复旦大学附属儿科医院中医科

来源：

国际儿科学杂志 | 2014年 / 41卷 / 04期

关键词：

GnIH/GPR147; Kisspeptin/GPR54; 促性腺激素释放激素; 青春期;

D O I：

暂无

中图分类号：

R33 [人体生理学];

学科分类号：

1001 ;

摘要：

小儿青春发育启动与下丘脑-垂体-性腺轴的发动有关,而下丘脑促性腺激素释放激素(gonadotropin-releasing hormone,GnRH)神经元的激活是青春期启动的关键。青春期启动过程是一个复杂的过程,GnRH又受到许多相关神经肽调节的影响。近来研究发现促性腺激素抑制激素(gonadotropin-inhibitory hormone,GnIH)和Kisspeptin分别能够抑制和促进哺乳类动物的下丘脑GnRH的分泌,提示GnIH和Kisspeptin对生殖内分泌轴起着非常重要的调节作用。因此,GnIH/GPR147和Kisspeptin/GPR54两条通路可能与小儿青春发育启动密切相关。

引用

页码：394 / 398

共 13 条

[1] KISS-1/GPR54基因及其在生殖中的作用 [J].

冯涛 ;

储明星 ;

张英杰 .

遗传, 2008, (04) :419-425

[2]

Control of GnRH secretion: One step back[J] . Iain J. Clarke.Frontiers in Neuroendocrinology . 2011 (3)

[3]

Anatomy of the kisspeptin neural network in mammals[J] . Michael N. Lehman,Christina M. Merkley,Lique M. Coolen,Robert L. Goodman.Brain Research . 2010

[4]

A new key neurohormone controlling reproduction, gonadotropin-inhibitory hormone (GnIH): Biosynthesis, mode of action and functional significance[J] . Kazuyoshi Tsutsui.Progress in Neurobiology . 2009 (1)

[5]

RFamide‐Related Peptide and its Cognate Receptor in the Sheep: cDNA Cloning, mRNA Distribution in the Hypothalamus and the Effect of Photoperiod[J] . H.Dardente,M.Birnie,G. A.Lincoln,D. G.Hazlerigg.Journal of Neuroendocrinology . 2008 (11)

[6]

Gonadotrophin‐Inhibitory Hormone Receptor Expression in the Chicken Pituitary Gland: Potential Influence of Sexual Maturation and Ovarian Steroids[J] . S.Maddineni,O. M.Ocón‐Grove,S. M.Krzysik‐Walker,G. L.Hendricks III,J. A.Proudman,R.Ramachandran.Journal of Neuroendocrinology . 2008 (9)

[7]

Reproductive functions of kisspeptin and Gpr54 across the life cycle of mice and men[J] . Yee-Ming Chan,Sarabeth Broder-Fingert,Stephanie B. Seminara.Peptides . 2008 (1)

[8]

Gonadotropin-inhibitory hormone and its receptor in the avian reproductive system[J] . George E. Bentley,Takayoshi Ubuka,Nicolette L. McGuire,Vishwajit S. Chowdhury,Yoshihiro Morita,Tetsu Yano,Itaru Hasunuma,Molly Binns,John C. Wingfield,Kazuyoshi Tsutsui.General and Comparative Endocrinology . 2007 (1)

[9] Human genetics of GPR54 [J].

Cerrato, Felecia ;

Seminara, Stephanie B. .

REVIEWS IN ENDOCRINE & METABOLIC DISORDERS, 2007, 8 (01) :47-55

[10]

The neuroendocrine physiology of kisspeptin in the human[J] . Waljit S Dhillo,Kevin G Murphy,Stephen R Bloom.Reviews in Endocrine and Metabolic Disorders . 2007 (1)

← 1 2 →