Enantioselective direct aldol-type reaction of 4-hydroxycoumarin with ethyl trifluoropyruvate catalyzed by modified cinchona alkaloids

被引：0
作者：
CUI HaiLei
机构：
来源：
Science Bulletin | 2010年 / 17期
关键词：
4-hydroxycoumarin; tertiary trifluoromethyl alcohol; asymmtric synthesis; cinchona alkaloid; organocatalysts;
D O I：
暂无
中图分类号：
O621.25 [];
学科分类号：
070303 ; 081704 ;
摘要：
A new enantioselective aldol-type reaction of 4-hydroxycoumarins and ethyl trifluoropyruvate has been developed. In the presence of (DHQD)2PHAL (5 mol%), ethyl trifluoropyruvate could react with various 4-hydroxycoumarins to afford novel 4-hydroxycoumarin derivatives containing a tertiary trifluoromethyl alcohol center in good yields with moderate enantioselectivities.
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页码：1732 / 1734
页数：3
相关论文
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