共 2 条
Relationship between insulinase activity of erythrocytes and insulin resistance in patients with type2diabetes mellitus
被引：0
作者：
李晨钟
张素华
邱鸿鑫
王鼎年
机构：
关键词：
insulinase;
insulinresistance;
diabetesmellitus;
type2;
D O I：
暂无
中图分类号：
R587.1 [糖尿病];
学科分类号：
1002 ;
100201 ;
摘要：
Objective:To investigatetherelationshipbetweeninsulinaseactivityof erythrocytes(EIA)andinsulin resistanceinpatientswithtype2diabetesmellitus.Methods:EIAwas determinedwiththemethodof radioassayof enzymeactivityin65healthysubjects,and109patientswithtype2diabetesmellitusdividedinto3subgroupsac-cordingto theirtherapy andplasmaglucosecontrol.Fastingplasmainsulin(FINS)andotherrelatedindiceswereal-so measuredinallthesubjects.Moreover,insulinsensitiveindex(ISI)wascalculatedforestimationof insulinsensi-tivity.Re sults:EIAandFINSareincreasedin two subgroupsof diabeticpatientson hypoglycemics(subgroupA andsubgroupB),andespeciallyhigherinthepoorcontrolled subgroupof patients(subgroupA).EIAandFINSare normalinsubgroupof patientswithoutmedication(subgroupC).Moreover,ISIis decreasedin allthesubgroupsof patientsas comparedwithnormalsubjects.CorrelationanalysisshowthatEIAis inverselycorrelatedwithISIinall subgroupsof patientsandnormalsubjects,andpositivelycorrelatedwithFINSin normalsubjects.Conclusions:Therateof insulindegradationin erythrocytesis increasedin patientswithtype2diabetes,and increasedinsulin degradationmayresultintheirinsulin-resistantstate.Moreover,EIAmaybe usedas oneof theindicesforestima-tionof insulinsensitivity.
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页码：138 / 141
页数：4
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