Role of IL-17 family cytokines in the progression of IPF from inflammation to fibrosis

被引：7

作者：

YunJuan Nie ^{[1
]}

ShuoHua Wu ^{[2
]}

YingHua Xuan ^{[3
]}

Gen Yan ^{[4
]}

机构：

[1] Department of Basic Medicine,Wuxi School of Medicine,Jiangnan University

[2] Department of Radiology,the Second Affiliated Hospital,Medical College of Shantou University

[3] Department of Basic Medicine,Xiamen Medical College

[4] Department of Radiology,the Second Affiliated Hospital of Xiamen Medical College

来源：

Military Medical Research | 2022年 / 9卷 / 05期

关键词：

D O I：

暂无

中图分类号：

R563 [肺疾病];

学科分类号：

1002 ; 100201 ;

摘要：

Idiopathic pulmonary fibrosis(IPF) is a fatal chronic interstitial lung disease with no established treatment and is characterized by progressive scarring of the lung tissue and an irreversible decline in lung function. Chronic inflammation has been demonstrated to be the pathological basis of fibrosis. Emerging studies have revealed that most interleukin-17(IL-17) isoforms are essential for the mediation of acute and chronic inflammation via innate and adaptive immunity. Overexpression or aberrant expression of IL-17 cytokines contributes to various pathological outcomes, including the initiation and exacerbation of IPF. Here, we aim to provide an overview of IL-17 family members in the pathogenesis of IPF.

引用

页码：618 / 627

页数：10

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