DeSUMOylation of protein kinase B1inhibits cell proliferation and metastasis of hepatocellular carcinoma

被引：0
|
作者：
盛凤 [1 ]
机构：
[1] TCM Dept,5th Centr Hosp
来源：
China Medical Abstracts(Internal Medicine) | 2018年 / 35卷 / 01期
关键词：
HCC; DeSUMOylation of protein kinase B1inhibits cell proliferation and metastasis of hepatocellular carcinoma;
D O I：
暂无
中图分类号：
R735.7 [肝肿瘤];
学科分类号：
摘要：
Objective To investigate the effect of AKT1 deSUMOylation induced by Ubc9 silencing on the proliferation and metastasis of hepatocellular carcinoma(HCC)cells.Methods The Ubc9 gene was silenced using RNA interference,and the expression levels of Ubc9,SUMO1 and AKT1 protein were detected by Western blot.Cell proliferation and cell cycle was analyzed by MTT and flow
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页码：49 / 49
页数：1
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