Effect of B vitamin supplementation on plasma homocysteine levels in celiac disease

被引:0
作者
Muhammed Hadithi [1 ]
Chris JJ Mulder [1 ]
Frank Stam [2 ]
Joshan Azizi [1 ]
J Bart A Crusius [3 ]
Amado Salvador Pea [3 ]
Coen DA Stehouwer [4 ]
Yvo M Smulders [2 ]
机构
[1] Department of Gastroenterology, VUmc University Medical Center, Amsterdam, PO Box 7057, Amsterdam 1007 MB, The Netherlands
[2] Department of Internal Medicine, VUmc University Medical Center, Amsterdam, PO Box 7057, Amsterdam 1007 MB, The Netherlands
[3] Laboratory of Immunogenetics, Department of Pathology, VUmc University Medical Center, Amsterdam, PO Box 7057, Amsterdam 1007 MB, The Netherlands
[4] Department of Internal Medicine, Academic Hospital Maastricht, P. Debyelaan 25, 6229 HX, Maastricht, The Netherlands
关键词
Celiac disease; Homocysteine; Vitamin supplements;
D O I
暂无
中图分类号
R572 [腹部疾病];
学科分类号
1002 ; 100201 ;
摘要
AIM: To investigate the effect of vitamin supplements on homocysteine levels in patients with celiac disease. METHODS: Vitamin B6, folate, vitamin B12, and fasting plasma homocysteine levels were measured in 51 consecutive adults with celiac disease [median (range) age 56 (18-63) years; 40% men, 26 (51%) had villous atrophy, and 25 (49%) used B-vitamin supplements] and 50 healthy control individuals matched for age and sex. Finally, the C677T polymorphism of 5,10-methylene tetrahydrofolate reductase (MTHFR) was evaluated in 46 patients with celiac disease and all control individuals. RESULTS: Patients with celiac disease and using vitamin supplements had higher serum vitamin B6 (P = 0.003),folate (P < 0.001), and vitamin B12 (P = 0.012) levels than patients who did not or healthy controls (P = 0.035, P < 0.001, P = 0.007, for vitamin B6, folate, and vitamin B12, respectively). Lower plasma homocysteine levels were found in patients using vitamin supplements than in patients who did not (P = 0.001) or healthy controls (P = 0.003). However, vitamin B6 and folate, not vitamin B12, were significantly and independently associated with homocysteine levels. Twenty-four (48%) of 50 controls and 23 (50%) of 46 patients with celiac disease carried the MTHFR thermolabile variant T-allele (P = 0.89). CONCLUSION: Homocysteine levels are dependent on Marsh classification and the regular use of B-vitamin supplements is effective in reduction of homocysteine levels in patients with celiac disease and should be considered in disease management.
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收藏
页码:955 / 960
页数:6
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