转录因子c-Maf在肾脏疾病中的作用研究进展

被引:1
|
作者
张甲倩
乔军
邱梦婷
张升校
李小峰
机构
[1] 不详
[2] 山西医科大学第二医院风湿免疫科
[3] 不详
关键词
转录因子; c-Maf; 痛风; 肾病综合征;
D O I
暂无
中图分类号
R692 [肾疾病];
学科分类号
摘要
原癌基因c-Maf是病毒癌基因v-Maf在细胞内存在保守碱性结构域及碱性亮氨酸拉链的同源基因,以同源或异源二聚体形式结合DNA,发挥转录激活功能,适度活化时可调节肾脏的胚胎发育、肾小管细胞分化、抗氧化及足细胞的功能,与痛风、肾病综合征等肾脏疾病的病理生理过程密切相关。c-Maf基因调控网络在肾脏疾病的早期诊断、治疗、预后中具有重要意义。该文旨在对转录因子c-Maf在肾脏疾病中的研究进展作一简要综述。
引用
收藏
页码:1167 / 1170
页数:4
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