MBD2调控Th17优势分化与非Th2优势型哮喘

被引：1
|
作者：
陈志锋 [1 ]
向旭东 [2 ]
机构：
[1] 中南大学湘雅二医院呼吸内科, 长沙
[2] 中南大学湘雅二医院急诊医学科,
来源：
国际呼吸杂志 | 2021年 / 41卷 / 04期
关键词：
白细胞介素17; 甲基化-CpG结合域蛋白2; 辅助性T细胞17; 非Th2优势型哮喘;
D O I：
暂无
中图分类号：
R562.25 [];
学科分类号：
摘要：
辅助性T细胞17(Th17)是近年发现的新CD4+T细胞亚群, 主要通过分泌细胞因子白细胞介素17趋化中性粒细胞在气道募集而促进非Th2优势型哮喘的发生。甲基化-CpG结合域蛋白在DNA甲基化中具有调控作用, 且能通过调控Th17分化而影响哮喘的进展。文中主要综述了近年甲基化-CpG结合域蛋白2调控Th17优势分化进而介导非Th2优势型哮喘的研究进展。
引用
收藏
页码：276 / 282
页数：7
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