Design and synthesis of cyclic acylguanidines as BACE1 inhibitors

被引：0

作者：

Jia-Kuo Liu ^{[1
]}

Wei Gu ^{[1
]}

Xiao-Rui Cheng ^{[1
]}

Jun-Ping Cheng ^{[1
]}

Wen-Xia Zhou ^{[1
]}

Ai-Hua Nie ^{[1
]}

机构：

[1] Beijing Institute of Pharmacology and Toxicology

来源：

Chinese Chemical Letters | 2015年 / 26卷 / 10期

基金：

中国国家自然科学基金;

关键词：

Alzheimer’s disease; BACE1; inhibitor; Cyclic acylguanidine;

D O I：

暂无

中图分类号：

TQ460.1 [基础理论];

学科分类号：

1007 ;

摘要：

Based on the lead compound 1 reported in literature, a series of novel BACE1 inhibitors were designed and synthesized, among which compound 11 exhibited a 14-fold improvement in potency over the lead compound 1. This represents a good lead for the discovery of more promising BACE1 inhibitors for the potential treatment of AD.

引用

页码：1327 / 1330

页数：4

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