One-step preparation of porous aminated-silica nanoparticles and their antibacterial drug delivery applications

Porous functionalized silica nanoparticles have attracted the interest of researchers as they are excellent carriers for antibacterial drug delivery applications.In this work,porous aminated-silica nanoparticles（SiO;-NH;NPs） were prepared via one-step approach through the ammonia-catalyzed hydrolysis of tetraethylorthosilicate（TEOS） and（3-aminopropyl） triethoxysilane（APTES） in a mixed water-ethanol system.The obtained SiO;-NH;NPs displayed a spherical morphology and relatively uniform size distribution,while the morphology and structure of SiO;-NH;NPs were mainly determined by the order of the reagents added and the pH value of the solution.After characterization,the results showed that there were a large number of-NH;groups on the surface of porous SiO;-NH;NPs and that the porous SiO;-NH;NPs had a large surface area of 476 m;g;with an average pore width of 4.3 nm.Through an absorbing-releasing experiment and bacterial test,those SiO;-NH;NPs were found to exhibit efficient absorption and release of drugs as well as a pH-de pendent release pattern of epirubicin-loaded SiO;-NH;NPs.Meanwhile,SiO;-NH;@capsaicin NPs exhibited antibacterial properties.Those porous SiO;-NH;NPs could be a candidate for drug delivery for antibacterial applications owing to their tailored porous structure and high surface area.