Dynamic changes of mG1uR1 mRNA expression in rat hippocampus during seizures induced by kainic acid

被引：0

作者：

江文

黄远桂

高华

肖华胜

机构：

来源：

JournalofMedicalCollegesofPLA | 2000年 / 01期

关键词：

epilepsy; metabotropic glutamate receptors; hippocampus; kainic acid; electroencephalogram;

D O I：

暂无

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Objective: To investigate temporospatial changes of mG1uR1 mRNA expression in rat hippocampus during seizures induced by kainic acid. Methods: Using in situ hybridization with Dig-labeled cDNA probes to examine mG1uR1 mRNA expression. The relative number of hybridization signal was quantified by image analysis systems. EEG and behavior changes of the rats were simultaneously observed. Results: All rats of the KA-injected group exhibited severe limbic convulsions. The EEG recordings also showed electrical seizure activities. The mG1uR1 mRNA expression began to increase at 1 h after KA injection and reached its maximal level at 4 - 8 h, and then it began to decrease gradually and came to the lowest by the end of 72 h. Conclusion: The enhanced early expression of mG1uR1 mRNA in hippocampus suggested that mG1uR1 may play an important role in epilepogenesis and may be related to the subsequent neuronal damage.

引用

页码：55 / 59

页数：5

共 9 条

[1]

Tizzano JP,Griffey KI,Schoepp DD.Induction or protection of limbic seizures inmice by mGluR subtype selective agonisls. Neuropharmacology . 1995

[2] Neurology [C].

The 5th International Congress of Pathophysiology

,2006

[3]

Pin JP,Duvoisin R.The metabotropic glutamate receptors: struetule and function. Neuropharmacology . 1995

[4]

Merlin LR,Wong RK.Role of group I metabotropic receptors in the patterning ofepileptiform activities in vitro. Journal of Neurophysiology . 1997

[5]

Shigemoto R,Nakanishi S,Mizuno N.Distribution Of the mRNA for ametabotropic glutamate receptor(mG1uR1 ) in the central nervous system: An insitu hybridization study in adult and developing rat. Journal of Comparative Neurology . 1992

[6]

Friedman LK,Pellegrini-Giampietro DE,Sperber EF et al.Kainate-inducedstatus epilepticus alters glutamate and GABAA receptor gene expression in adultrat hippocampus: An in situ hybridization study. The Journal of Neuroscience . 1994

[7]

Sperk G.Kainic acid seizeals in the rat. Progress in Neurobiology . 1994

[8]

Akbar MT,Rattray M,Powell JF et al.Altered expression of group letabotropicglutamate receptors in the hippocampus of amygdala-kindled rats. Molecular Brain Research . 1996

[9]

Dalby NO,Thomsen C.Modulation of seizure activity in mice by metabotropicglutamate receptor ligands. Journal of Pharmacology and Experimental Therapeutics . 1996

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