An efficient synthesis of substituted 1,4-diazepines by a Pd catalyzed amination and sequential hydrogenation condensation

被引：2

作者：

Xiao-Jian Wang ^{[1
]}

Yu-Lin Tian ^{[1
]}

Qing-Yang Zhang ^{[1
]}

Jian-Guo Qi ^{[1
]}

Da-Li Yin ^{[1
]}

机构：

[1] State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Beijing Key Laboratory of Active Substance Discovery and Druggability Evaluation,Institute of Materia Medica,Peking Union Medical College and Chinese Academy of Medical Sciences

来源：

ChineseChemicalLetters | 2013年 / 24卷 / 08期

基金：

中国国家自然科学基金;

关键词：

1,4-Diazepines; Pd-catalyzed amination; Hydrogenation; Intramolecular condensation;

D O I：

暂无

中图分类号：

O643.32 [催化反应];

学科分类号：

081705 ;

摘要：

An efficient synthesis of substituted 1,4-diazepines is developed.The accessible intermediates have been obtained via Pd-catalyzed amination.The subsequent hydrogenation and intramolecular condensation sequences could be conducted successively in one pot without special operation.The mild and general strategy enables the synthesis of various substituted 1,4-diazepines in high yields.

引用

页码：743 / 746

页数：4