ANGIOTENSIN Ⅱ-INDUCED CELLULAR HYPERTROPHY: POTENTIAL ROLE OF THE PROTEOLYTIC ACTIVITY IN CULTURED PROXIMAL TUBULE CELLS (LLC-PK1)

被引:0
作者
Liliana Schaefer
Spiros Vamuakas
Roland M Schaefer
Markus Teschner
August Heidiand
机构
[1] Division of Nephrology. University of Wuerzburg
[2] Germany
关键词
LLC-PK1; POTENTIAL ROLE OF THE PROTEOLYTIC ACTIVITY IN CULTURED PROXIMAL TUBULE CELLS; INDUCED CELLULAR HYPERTROPHY; PK; ANGIOTENSIN;
D O I
暂无
中图分类号
R692 [肾疾病];
学科分类号
1002 ; 100210 ;
摘要
In a number of renal disease tubular epithelial cells often display hypertrophy rather than hyperplasia. This hypertrophy, characterized by an increase in protein conten and cell size, as well as an accumulation of extracellular matrix, is a key process which may lead subsequently to tubulointerstitial fibrosis and end-stage renal failure.
引用
收藏
页码:77 / 77
页数:1
相关论文
共 50 条
  • [1] ANGIOTENSIN-II-INDUCED CELL HYPERTROPHY - POTENTIAL ROLE OF IMPAIRED PROTEOLYTIC ACTIVITY IN CULTURED LLC-PK1 CELLS
    LING, H
    VAMVAKAS, S
    SCHAEFER, L
    SCHNITTLER, HJ
    SCHAEFER, RM
    HEIDLAND, A
    NEPHROLOGY DIALYSIS TRANSPLANTATION, 1995, 10 (08) : 1305 - 1312
  • [2] ANGIOTENSIN-II STIMULATES CELLULAR HYPERTROPHY OF LLC-PK1 CELLS THROUGH THE AT1 RECEPTOR
    WOLF, G
    ZAHNER, G
    MONDORF, U
    SCHOEPPE, W
    STAHL, RAK
    NEPHROLOGY DIALYSIS TRANSPLANTATION, 1993, 8 (02) : 128 - 133
  • [3] Uptake of doxorubicin by cultured kidney epithelial cells LLC-PK1
    Sasaya, M
    Wada, I
    Shida, M
    Sato, M
    Hatakeyama, Y
    Saitoh, H
    Takada, M
    BIOLOGICAL & PHARMACEUTICAL BULLETIN, 1998, 21 (05) : 527 - 529
  • [4] The transport of ciprofloxacin in cultured kidney epithelial cells LLC-PK1
    Sasaya, M
    Oda, M
    Endo, T
    Saitoh, H
    Takada, M
    BIOLOGICAL & PHARMACEUTICAL BULLETIN, 1997, 20 (08) : 887 - 891
  • [5] The transport of enoxacin in cultured kidney epithelial cells LLC-PK1
    Sasaya, M
    Shida, M
    Hirano, T
    Oda, M
    Endo, T
    Sakata, M
    Miyazaki, S
    Takada, M
    YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 1996, 116 (06): : 497 - 503
  • [6] Effect of cyclosporin A on nitric oxide production in cultured LLC-PK1 cells
    Lima, R
    Serone, AP
    Schor, N
    Higa, EMS
    RENAL FAILURE, 2001, 23 (01) : 43 - 52
  • [7] Urinary Excretion of Tetrodotoxin Modeled in a Porcine Renal Proximal Tubule Epithelial Cell Line, LLC-PK1
    Matsumoto, Takuya
    Ishizaki, Yui
    Mochizuki, Keika
    Aoyagi, Mitsuru
    Mitoma, Yoshiharu
    Ishizaki, Shoichiro
    Nagashima, Yuji
    MARINE DRUGS, 2017, 15 (07):
  • [8] LLC-PK1 cells as a model system to study proximal tubule transport of water and other compounds relevant for renal stone disease
    Verkoelen, CF
    Kok, DJ
    van der Boom, BG
    de Jonge, HR
    Schröder, FH
    Romijn, JC
    UROLOGICAL RESEARCH, 1999, 27 (02): : 109 - 115
  • [9] Sphingosine mediates FTY720-induced apoptosis in LLC-PK1 cells
    Lee, WJ
    Yoo, HS
    Suh, PG
    Lim, JS
    Oh, S
    Lee, YM
    EXPERIMENTAL AND MOLECULAR MEDICINE, 2004, 36 (05) : 420 - 427
  • [10] Cisplatin-induced toxicity in LLC-PK1 kidney epithelial cells:: role of basolateral membrane transport
    Okuda, M
    Tsuda, K
    Masaki, K
    Hashimoto, Y
    Inui, K
    TOXICOLOGY LETTERS, 1999, 106 (2-3) : 229 - 235