A new facile synthesis of shikalkin

被引：0

作者：

Qun Lu a Hao Lun Tang a Yan Qiang Shao a Jun Chao Cai b a Department of Bioengineering Southwest Jiaotong University Chengdu China b Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai China ^{[610031
,200031
]}

机构：

来源：

ChineseChemicalLetters | 2008年 / 02期

关键词：

Synthesis; Shikalkin; Epoxides;

D O I：

暂无

中图分类号：

O621.3 [有机合成化学];

学科分类号：

070303 ; 081704 ;

摘要：

A short and convergent approach for the synthesis of shikalkin (dl-shikonin) is presented. Stobbe reaction was employed to construct the aromatic skeleton 6. This is followed by a practical method to prepare the key epoxides 9 from aldehydes 8 in high yield. Finally, shikalkin is achieved by Grignard reaction and oxidation.

引用

页码：172 / 174

页数：3

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