Impurity analysis of gentamicin bulk samples by improved liquid chromatography-ion trap mass spectrometry

被引：0

作者：

HOOGMARTENS Jos ^{[1
]}

SCHEPDAEL Ann Van ^{[1
]}

ADAMS Erwin ^{[1
]}

机构：

[1] Katholieke Universiteit Leuven,Faculteit Farmaceutische Wetenschappen,Laboratorium voor Farmaceutische Analyse

来源：

Science China(Chemistry) | 2011年 / 09期

关键词：

gentamicin; liquid chromatography; LC/MS; impurity analysis;

D O I：

暂无

中图分类号：

TQ465 [抗菌素制造];

学科分类号：

100705 ;

摘要：

Several gentamicin bulk samples from different origins were investigated using an LC/MS method.LC equipped with ion trap MS with positive ionization was performed on a Capcell Pak C18(AQ) column with the mobile phase containing 50 mM trifluoroacetic(TFA) and methanol.Impurities present in batches of gentamicin bulk samples were elucidated and compared according to their fragmentation behavior.In total seventeen impurities present in samples,five impurities were not elucidated and two compounds were identified preliminarily.It was observed that the impurity profiles were different in samples from different origins which indicate necessity in the quality control of gentamicin.

引用

页码：1518 / 1528

页数：11

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