Impurity analysis of gentamicin bulk samples by improved liquid chromatography-ion trap mass spectrometry

被引：0
|
作者：
HOOGMARTENS Jos [1 ]
SCHEPDAEL Ann Van [1 ]
ADAMS Erwin [1 ]
机构：
[1] Katholieke Universiteit Leuven,Faculteit Farmaceutische Wetenschappen,Laboratorium voor Farmaceutische Analyse
来源：
Science China(Chemistry) | 2011年 / 09期
关键词：
gentamicin; liquid chromatography; LC/MS; impurity analysis;
D O I：
暂无
中图分类号：
TQ465 [抗菌素制造];
学科分类号：
100705 ;
摘要：
Several gentamicin bulk samples from different origins were investigated using an LC/MS method.LC equipped with ion trap MS with positive ionization was performed on a Capcell Pak C18(AQ) column with the mobile phase containing 50 mM trifluoroacetic(TFA) and methanol.Impurities present in batches of gentamicin bulk samples were elucidated and compared according to their fragmentation behavior.In total seventeen impurities present in samples,five impurities were not elucidated and two compounds were identified preliminarily.It was observed that the impurity profiles were different in samples from different origins which indicate necessity in the quality control of gentamicin.
引用
收藏
页码：1518 / 1528
页数：11
相关论文
共 50 条
  • [1] Impurity analysis of gentamicin bulk samples by improved liquid chromatography-ion trap mass spectrometry
    Chao Zheng
    BoChu Wang
    MingJuan Wang
    Jos Hoogmartens
    Ann Van Schepdael
    Erwin Adams
    Science China Chemistry, 2011, 54 : 1518 - 1528
  • [2] Impurity analysis of gentamicin bulk samples by improved liquid chromatography-ion trap mass spectrometry
    Zheng Chao
    Wang BoChu
    Wang MingJuan
    Hoogmartens Jos
    Schepdael Ann Van
    Adams Erwin
    SCIENCE CHINA-CHEMISTRY, 2011, 54 (09) : 1518 - 1528
  • [3] Impurity profiling of micronomicin sulfate injection by liquid chromatography-ion trap mass spectrometry
    Yuan, Yao-zuo
    Zhao, Xun
    Zhang, Mei
    Fan, Xia-Lei
    Hu, Chang-qin
    Jin, Shao-hong
    Van Schepdael, Ann
    Hoogmartens, Jos
    Adams, Erwin
    JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2013, 75 : 94 - 104
  • [4] Analysis of perfluorooctanesulfonate and related fluorochemicals in water and biological tissue samples by liquid chromatography-ion trap mass spectrometry
    Tseng, CL
    Liu, LL
    Chen, CM
    Ding, WH
    JOURNAL OF CHROMATOGRAPHY A, 2006, 1105 (1-2) : 119 - 126
  • [5] Comparison of four extraction methods for the analysis of 24 pesticides in soil samples with gas chromatography-mass spectrometry and liquid chromatography-ion trap-mass spectrometry
    Lesueur, C.
    Gartner, M.
    Mentler, A.
    Fuerhacker, M.
    TALANTA, 2008, 75 (01) : 284 - 293
  • [6] Determination of fungicide residues in baby food by liquid chromatography-ion trap tandem mass spectrometry
    Gilbert-Lopez, Bienvenida
    Garcia-Reyes, Juan F.
    Molina-Diaz, Antonio
    FOOD CHEMISTRY, 2012, 135 (02) : 780 - 786
  • [7] Improved detection of polyunsaturated fatty acids as phenacyl esters using liquid chromatography-ion trap mass spectrometry
    Nichols, DS
    Davies, NW
    JOURNAL OF MICROBIOLOGICAL METHODS, 2002, 50 (02) : 103 - 113
  • [8] Identification and quantification of glucosinolates in rapeseed using liquid chromatography-ion trap mass spectrometry
    Millan, Silvia
    Carmen Sampedro, M.
    Gallejones, Patricia
    Castellon, Ander
    Ibargoitia, Maria L.
    Aranzazu Goicolea, M.
    Barrio, Ramon J.
    ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2009, 394 (06) : 1661 - 1669
  • [9] Pharmaceutical trace analysis in aqueous environmental matrices by liquid chromatography-ion trap tandem mass spectrometry
    Madureira, Tania Vieira
    Barreiro, Juliana Cristina
    Rocha, Maria Joao
    Cass, Quezia Bezerra
    Tiritan, Maria Elizabeth
    JOURNAL OF CHROMATOGRAPHY A, 2009, 1216 (42) : 7033 - 7042
  • [10] Analysis of pesticides in fruits by pressurized liquid extraction and liquid chromatography-ion trap-triple stage mass spectrometry
    Blasco, C
    Font, G
    Picó, Y
    JOURNAL OF CHROMATOGRAPHY A, 2005, 1098 (1-2) : 37 - 43
12345