养血清脑颗粒治疗卒中后抑郁的疗效及对脑白质结构改变的影响

被引：15

作者：

许孝南 ^{[1
]}

马婷 ^{[2
]}

陈旭辉 ^{[1
]}

虢周科 ^{[3
]}

朱治山 ^{[4
]}

刘淑云 ^{[5
]}

李梅笑 ^{[6
]}

李晶 ^{[7
]}

刘相城 ^{[5
]}

吴军 ^{[1
]}

机构：

[1] 北京大学深圳医院神经内科

[2] 哈尔滨工业大学深圳研究生院

[3] 深圳市中医院神经内科

[4] 深圳市罗湖区人民医院神经内科

[5] 深圳市龙华新区人民医院神经内科

[6] 深圳市龙岗区人民医院神经内科

[7] 深圳市宝安区沙井人民医院神经内科

来源：

中风与神经疾病杂志 | 2016年 / 33卷 / 05期

关键词：

卒中后抑郁; 弥散张量成像; 疗效; 养血清脑颗粒;

D O I：

10.19845/j.cnki.zfysjjbzz.2016.05.012

中图分类号：

R743.3 [急性脑血管疾病（中风）]; R749.4 [情感性精神病];

学科分类号：

1002 ; 100205 ;

摘要：

目的利用磁共振弥散张量成像(DTI)技术,观察养血清脑颗粒治疗卒中后抑郁(PSD)的疗效差异,以及其对脑白质结构改变的影响。方法给予卒中后抑郁患者养血清脑颗粒4 g,口服,3次/d;疗程12 w,治疗前、后均收集汉密尔顿抑郁量表评分(HAMD-24)、DTI扫描数据。治疗后HAMD-24≤8分纳入治愈组,反之纳入难治组。比较两组治疗前、后FA值变化情况。结果养血清脑颗粒治愈率约44.6%。与治疗前相比,治愈组的左侧额叶FA值治疗后明显升高(P<0.05);比较两组治疗前的FA值,发现难治组左侧额叶、右侧海马的基线FA值低下(P<0.05)。结论养血清脑颗粒治疗PSD有效。PSD患者存在可逆性前额叶深部白质损伤;且难治性PSD患者左侧额叶、右侧海马的基线FA值低下,提示DTI可作为抗抑郁疗效评估的预测指标。

引用

页码：438 / 441

页数：4

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