Activation of bone morphogenetic protein-6 gene transcription in MCF-7 cells by estrogen

被引：0
|
作者：
ZHANG Ming
机构：
来源：
中华医学杂志(英文版) | 2005年 / 19期
关键词：
bone morphogenetic protein-6 · estrogen · chromatin immunoprecipitation · site-directed mutagenesis;
D O I：
暂无
中图分类号：
R341 [];
学科分类号：
1001 ;
摘要：
Bone morphogenetic protein-6 (BMP-6), which belongs to the transforming growth factor-β (TGF-β) superfamily, is a multifunctional molecule that regulates bone growth and organ development. Besides the common characteristics of BMP family members that induce chondrocyte differentiation and endochondral bone formation,~1 BMP-6 is overexpressed in breast cancer, prostate cancer and salivary gland cancer, and is speculated to be closely associated with skeletal metastasis.~ 2-5
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页码：47 / 54
页数：8
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