Proton pump inhibitor responsive esophageal eosinophilia,a distinct disease entity?

被引：1

作者：

William Munday ^{[1
]}

Xuchen Zhang ^{[2
]}

机构：

[1] Department of Pathology,Yale University School of Medicine,New Haven,CT 06520,United States

[2] Department of Pathology,VA Connecticut Health System and Yale University School of Medicine,West Haven,CT 06516,United States

来源：

World Journal of Gastroenterology | 2014年 / 20卷 / 30期

关键词：

Gastroesophageal reflux disease; Eosinophilic esophagitis; Proton pump inhibitor responsive esophageal eosinophilia; Proton pump inhibitor;

D O I：

暂无

中图分类号：

R571 [食管疾病];

学科分类号：

1002 ; 100201 ;

摘要：

Recent studies have suggested the existence of a patient population with esophageal eosinophilia that responds to proton pump inhibitor therapy.These patients are being referred to as having proton pump inhibitor responsive esophageal eosinophilia(PPI-REE),which is currently classified as a distinct and separate disease entity from both gastroesophageal reflux disease(GERD)and eosinophilic esophagitis(EoE).The therapeutic effect of proton pump inhibitor(PPI)on PPI-REE is thought to act directly at the level of the esophageal mucosa with an anti-inflammatory capacity,and completely independent of gastric acid suppression.The purpose of this manuscript is to review the mechanistic data of the proposed immune modulation/anti-inflammatory role of the PPI at the esophageal mucosa,and the existence of PPI-REE as a distinct disease entity from GERD and EoE.

引用

页码：10419 / 10424

页数：6

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