A murine model of dengue virus infection in suckling C57BL/6 and BALB/c mice

被引：0

作者：

Alana BByrne ^{[1
,2
,3
]}

Ayeln GGarca ^{[1
,4
]}

Jorge MBrahamian ^{[1
,2
,5
]}

Aldana Mauri ^{[1
]}

Adrin Ferretti ^{[1
]}

Fernando PPolack ^{[1
]}

Laura BTalarico ^{[1
,2
,3
]}

机构：

[1] Fundación INFANT

[2] Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET)

[3] Laboratorio de Investigaciones Infectológicas y Biología Molecular , Infectología , Departamento de Medicina,Hospital de Ni?os Ricardo Gutiérrez

[4] Instituto Nacional de Enfermedades Infecciosas (INEI) Administración Nacional de Laboratoriose Institutos de Salud (ANLIS) “Dr Carlos Malbrán”

[5] Departamento de Química Biológica-IQUIBICEN (CONICETUBA) , Facultad de Ciencias Exactas y Naturales , Universidad de Buenos Aires

来源：

Animal Models and Experimental Medicine | 2021年 / 4卷 / 01期

关键词：

BALB/c; C57BL/6; dengue virus; mouse model; suckling mice;

D O I：

暂无

中图分类号：

R512.8 [病毒性出血热]; R-332 [医用实验动物学];

学科分类号：

100401 ; 1001 ;

摘要：

Dengue is a significant public health concern across tropical and subtropical regions worldwide,principally causing disease in children. Very young children are at increased risk of severe manifestations of dengue infection. The mechanism of dengue disease in this population is not fully understood. In this study,we present a murine model of dengue virus primary infection in suckling C57 BL/6 and BALB/c mice in order to investigate disease pathogenesis. Three-day-old C57 BL/6 mice intraperitoneally infected with DENV-2 NGC were more susceptible to infection than BALB/c mice,showing increased liver enzymes,extended viremia,dissemination to organs and histological alterations in liver and small intestine. Furthermore,the immune response in DENV-infected C57 BL/6 mice exhibited a marked Th1 bias compared to BALB/c mice. These findings highlight the possibility of establishing an immunocompetent mouse model of DENV-2 infection in suckling mice that reproduces certain signs of disease observed in humans and that could be used to further study agerelated mechanisms of dengue pathogenesis.

引用

页码：16 / 26

页数：11

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