STAT3与黑素瘤

被引：1

作者：

孙兆军 ^{[1
]}

刘厚君 ^{[1
]}

涂亚庭 ^{[1
]}

机构：

[1] 华中科技大学同济医学院附属协和医院皮肤科

来源：

国际皮肤性病学杂志 | 2008年 / 03期

关键词：

黑色素瘤; 信号转导; 转录激活因子类;

D O I：

暂无

中图分类号：

R739.5 [皮肤肿瘤];

学科分类号：

100214 ;

摘要：

信号转导与转录激活因子3(STAT3)既是一种胞质信号分子又是胞核转录因子,参与细胞的存活、增殖、转化及迁移等过程。它在肿瘤如黑素瘤的发病中起着非常重要的作用,通过调节基因表达促进黑素瘤细胞的生长而参与肿瘤细胞的存活与增殖;通过诱导基因的表达促进黑素瘤细胞转移和肿瘤血管生成,参与调节肿瘤免疫侵袭所致的肿瘤免疫耐受。通过向目的细胞内引入STAT3反义寡核苷酸、诱饵寡核苷酸或显性负相蛋白等阻断STAT3的功能,可抑制目的细胞的增殖,促进细胞的死亡。

引用

共 44 条

[1] Matrix metalloproteinases and the development of cancer
Coussens, LM
Werb, Z
[J]. CHEMISTRY & BIOLOGY, 1996, 3 (11): : 895 - 904
[2] Matrix metalloproteinases and the development of cancer
Coussens, LM
Werb, Z
[J]. CHEMISTRY & BIOLOGY, 1996, 3 (11): : 895 - 904
[3] DOES THE IMMUNE SYSTEM SEE TUMORS AS FOREIGN OR SELF?[J] . Drew Pardoll. &nbspAnnual Review of Immunology . 2003
[4] DOES THE IMMUNE SYSTEM SEE TUMORS AS FOREIGN OR SELF?[J] . Drew Pardoll. &nbspAnnual Review of Immunology . 2003
[5] Bowman T,Garcia R,Turkson J et al STATs in oncogenesis. Oncegene . 2000
[6] Bowman T,Garcia R,Turkson J et al STATs in oncogenesis. Oncegene . 2000
[7] Regulation of the innate and adaptive immune responses by Stat-3signaling in tumor cells. Wang T,Niu G,Kortylewski M,et al. Nature Medicine . 2004
[8] Regulation of the innate and adaptive immune responses by Stat-3signaling in tumor cells. Wang T,Niu G,Kortylewski M,et al. Nature Medicine . 2004
[9] Does the immune system see tumors as foreign or self?. Pardoll D. Annual Review of Immunology . 2003
[10] Does the immune system see tumors as foreign or self?. Pardoll D. Annual Review of Immunology . 2003

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