无细胞百日咳疫苗研发与接种现状及前景

被引：3

作者：

崔乐乐 ^{[1
]}

谌志筠 ^{[1
]}

何秋水 ^{[1
,2
]}

机构：

[1] 首都医科大学基础医学院病原生物学系

[2] 芬兰图尔库大学医学微生物和免疫学系

来源：

中国生物制品学杂志 | 2023年 / 36卷 / 02期

基金：

北京市自然科学基金;

关键词：

百日咳; 无细胞百日咳疫苗; 抗原; 免疫接种; 免疫反应;

D O I：

10.13200/j.cnki.cjb.003821

中图分类号：

R392-33 [免疫学技术、设备及实验方法];

学科分类号：

100102 ;

摘要：

百日咳是传染性极强的呼吸系统疾病，主要影响婴幼儿。接种疫苗是预防百日咳感染的有效措施。无细胞百日咳疫苗(acellular pertussis vaccines,aPVs)因副作用更小，在许多国家已取代全细胞百日咳疫苗(whole-cell pertussis vaccines,wPVs)。尽管疫苗接种覆盖率较高，但aPVs的免疫力维持时间较短，被认为是百日咳重现的重要原因。针对百日咳疫苗的改进，基因脱毒疫苗及减毒活疫苗已取得了明显的临床效果，其他改进策略包括在现有aPVs中使用新型佐剂、增加抗原，或采用纳米颗粒包装等也具有良好的发展前景。本文就目前aPVs的抗原组分和保护效果，不同国家的接种程序，及潜在的百日咳疫苗候选组分和预防百日咳的新策略作一综述。

引用

页码：235 / 239+244 +244

页数：6

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