Enzyme responsive supramolecular hydrogels assembled from nonionic peptide amphiphiles

被引：0

作者：

Rui Liu ^{[1
,2
]}

Zhekun Shi ^{[1
,2
]}

Jing Sun ^{[1
,2
]}

Zhibo Li ^{[1
,2
]}

机构：

[1] Key Laboratory of Biobased Polymer Materials, Shandong Provincial Education Department

[2] School of Polymer Science and Engineering,Qingdao University of Science and Technology

来源：

Science China(Chemistry) | 2018年 / 10期

关键词：

oligopeptides; ring-opening polymerization; hydrogel; nanogel; enzyme responsive;

D O I：

暂无

中图分类号：

O648.17 [凝胶及软胶];

学科分类号：

070304 ; 081704 ;

摘要：

Smart peptide hydrogels are of great interest for their great potential applications. Here, we report a facile approach to prepare a class of enzyme-responsive hydrogels in a scalable manner. These hydrogels self-assemble from a family of nonionic peptide amphiphiles(PAs) synthesized by sequential ring-opening polymerization(ROP) of γ-benzyl-L-glutamate N-carboxyanhydride(BLG-NCA) and L-tyrosine N-carboxyanhydride(Tyr-NCA), followed by subsequent aminolysis. These PA samples can readily form a clear hydrogel with a critical gelation concentration as low as 0.5 wt%. The incorporation of tyrosine residues offers hydrophobicity, hydrogen-bonding interaction and enzyme-responsive properties. The hydrogel-to-nanogel transition is observed under physiological conditions in the presence of horseradish peroxidase(HRP) and hydrogen peroxide(H2 O2). The obtained PA hydrogels are ideal candidates for the new generation of smart scaffolds.

引用

页码：1314 / 1319

页数：6