Nanocarrier based on the assembly of protein and antisense oligonucleotide to combat multidrug resistance in tumor cells

被引：0

作者：

Xuan Yu ^{[1
]}

Liang Gong ^{[1
]}

Jing Zhang ^{[1
]}

Zilong Zhao ^{[1
]}

Xiaobing Zhang ^{[1
]}

Weihong Tan ^{[1
]}

机构：

[1] Molecular Science and Biomedicine Laboratory, State Key Laboratory for Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Life Sciences, and Aptamer Engineering Center of Hunan Province, Hunan University

来源：

Science China(Chemistry) | 2017年 / 10期

基金：

中国国家自然科学基金;

关键词：

multi-drug resistance; P-glycoprotein; antisense oligonucleotide; nanocarrier;

D O I：

暂无

中图分类号：

R73-36 [治疗实验]; TB383.1 [];

学科分类号：

070205 ; 080501 ; 100214 ; 1406 ;

摘要：

Chemotherapy-induced multi-drug resistance（MDR） in tumors poses a huge challenge for clinical treatment of tumors. The downregulation of the multi-drug resistance relative protein, represented by P-glycoprotein（P-gp）, can reverse MDR of cancer cells. In this study, we developed doxorubicin-loading nanocarrier based on the assembly of protein and antisense oligonucleotide（ASO） to combat MDR of cancer cells. The data demonstrate that the nanocarrier can efficiently deliver ASO to cytoplasm and downregulate the P-glycoprotein expression, subsequently improving the therapeutic effects of Dox in doxorubicin-resistant MCF-7/ADR cancer cells. The preparation is simple and effective, providing a powerful tool for gene delivery. Therefore, our nanocarrier shows high promise in cancer treatment.

引用

页码：1318 / 1323

页数：6

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