Ent-kaurane and ent-abietane diterpenoids from Isodon phyllostachys

被引：0
|
作者：
Jin Yang [1 ,2 ]
Yaqi An [1 ,2 ]
Haiyan Wu [1 ,2 ]
Miao Liu [1 ,2 ]
Weiguang Wang [1 ]
Xue Du [1 ]
Yan Li [1 ]
Jianxin Pu [1 ]
Handong Sun [1 ]
机构：
[1] State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences
[2] University of Chinese Academy of Sciences
来源：
Science China(Chemistry) | 2016年 / 09期
基金：
中国国家自然科学基金; 中国科学院西部之光基金;
关键词：
Isodon phyllostachys; diterpenoid; ent-kaurane; ent-abietane;
D O I：
暂无
中图分类号：
O629 [天然化合物]; TQ460.1 [基础理论];
学科分类号：
070303 ; 081704 ; 1007 ;
摘要：
Four new diterpenoids, phyllostachysins I–L(1–4), along with a known one, hebeiabinin B(5), were isolated from the aerial parts of Isodon phyllostachys(I. phyllostachys). Compounds 1 and 2 feature an ent-kaurane backbone, and 3, 4 and 5 bear an ent-abietane skeleton. Their structures were elucidated by means of spectroscopic analysis. Compounds 3 and 4 exhibited significant cytotoxic activity against human tumor cell lines(HL-60, SMMC-7721, A-549, MCF-7 and SW-480), and strongly inhibited NO production in LPS-stimulated RAW264.7 cells.
引用
收藏
页码：1211 / 1215
页数：5
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