Design of antibacterial peptide-like conjugated molecule with broad spectrum antimicrobial ability

被引：0

作者：

Hui Chen ^{[1
]}

Meng Li ^{[1
]}

Zhang Liu ^{[2
]}

Rong Hu ^{[1
]}

Shengliang Li ^{[1
]}

Yuan Guo ^{[1
]}

Fengting Lv ^{[1
]}

Libing Liu ^{[1
]}

Yilin Wang ^{[2
]}

Yuanping Yi ^{[1
]}

Shu Wang ^{[1
]}

机构：

[1] Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences

[2] Key Laboratory of Colloid, Interface and Chemical Thermodynamics, Institute of Chemistry,Chinese Academy of Sciences

来源：

Science China(Chemistry) | 2018年 / 01期

基金：

中国国家自然科学基金;

关键词：

OFBT; broad spectrum; antimicrobial activity;

D O I：

暂无

中图分类号：

TQ465 [抗菌素制造];

学科分类号：

100705 ;

摘要：

Increasing multidrug-resistant(MDR) superbugs emerge worldwide causing a public health crisis. Consequently, it is urgent to find new antibiotics with efficient broad-spectrum antimicrobial activity. By virtue of versatility in molecular design, a new peptide-like cell membrane-broken molecule, oligo-(7,7′-bifluoren-benzo[c][1,2,5]thiadiazole)(OFBT) possessing a conjugated backbone and eight pendant guanidyl moieties was designed and synthesized. OFBT exhibits favorable broad-spectrum of antimicrobial activity to pathogens including Gram-negative and Gram-positive bacteria, and fungi with the minimum inhibitory concentration(MIC)below 3.0 μM. Moreover, OFBT exhibits high selectivity for pathogens over human cells to make it a promising broad spectrum antimicrobial agent.

引用

页码：113 / 117

页数：5