A differentially methylated region of the DAZ1 gene in spermatic and somatic cells

被引：0
|
作者：
Zuo-Xiang Li~(1
机构：
来源：
Asian Journal of Andrology | 2006年 / 01期
关键词：
DAZ1; gene; DNA methylation; CpG island; methylated region; spermatogenesis;
D O I：
暂无
中图分类号：
R346 [];
学科分类号：
1001 ;
摘要：
Aim:To investigate the methylation status of the deleted in azoospermia 1(DAZ1)gene promoter region in differentcell types.Methods:Using CpG island Searcher software,a CpG island was found in the promoter region of theDAZ1 gene.The methylation status of this region was analyzed in sperm and leukocytes by bisulfited sequencing.Results:The methylation status of the CpG island in the DAZ1 gene promoter region differed in leukocytes andsperm:it was methylated in leukocytes,but unmethylated in sperm.Conclusion:A differentially methylated region ofthe DAZ1 gene exists in spermatic and somatic cells,suggesting that methylation of this region may regulate DAZ1gene expression in different tissues.(Asian J Androl 2006 Jan;8:61-67)
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页码：61 / 67
页数：7
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