A novel reductive ring-opening reaction of isoxazolidine to form functionalized 1,3-aminoalcohol

被引：0

作者：

Wing Hong Chan ^{[1
]}

Albert W.M. Lee ^{[1
]}

Wai Yeung Wong ^{[1
]}

机构：

[1] Department of Chemistry Hong Kong Baptist University Kowloog Tong Hong Kong

来源：

Chinese Chemical Letters | 2007年 / 06期

关键词：

Isoxazolidine; Hydrogenation; Raney nickel; 1,3-Amino-alcohol;

D O I：

暂无

中图分类号：

O621.25 [];

学科分类号：

070303 ; 081704 ;

摘要：

Reductive cleavage of the N-O bond of isoxazolidine ring with catalytic hydrogenation over Raney nickel was described. Bicyclic isoxazolidines could be effectively converted into the corresponding 1,3-amino-alcohol possessing a sultone or sultam moiety with high conversion and yield when the hydrogenation was catalyzed by freshly prepared Raney nickel under a pressure of 40 psi in the presence of triethylamine.

引用

页码：629 / 632

页数：4

共 4 条

[1] A novel reductive ring-opening reaction of isoxazolidine to form functionalized 1,3-aminoalcohol
Zhang, Hong Kui
Chan, Wing Hong
Lee, Albert W. M.
Xia, Ping Fang
Wong, Wai Yeung
CHINESE CHEMICAL LETTERS, 2007, 18 (06) : 629 - 632
[2] Palladium/Lewis Acid Cocatalyzed Reductive Asymmetric Ring-Opening Reaction of Azabenzonorbornadienes with Tertiary Amines as the Hydrogen Source
Zhang, Dapeng
Khan, Ruhima
Yang, Fan
Zhang, Xuexin
Shen, Guoli
Gao, Yang
Fan, Ruifeng
Sun, Weiqing
Fan, Baomin
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2018, 2018 (26) : 3464 - 3470
[3] Preparation of Multivalent Carbohydrate Mimetics Based on Enantiopure 1,2-Oxazines by Sonogashira Coupling and Subsequent Reductive Ring-Opening
Kandziora, Maja
Reissig, Hans-Ulrich
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2015, 2015 (02) : 370 - 377
[4] Synthesis of 2-bromo-1-aryl-1H-indenes via a Ag(I) promoted domino 2π-electrocyclic ring-opening/4π-electrocyclization reaction of 1,2-diaryl substituted gem-dibromocyclopropanes
Rosocha, Gregory
Batey, Robert A.
TETRAHEDRON, 2013, 69 (41) : 8758 - 8768

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