Adhesion-enhancing coating embedded with osteogenesis-promoting PDA/HA nanoparticles for peri-implant soft tissue sealing and osseointegration

被引：0

作者：

Tingshu Su ^{[1
,2
,3
]}

Ao Zheng ^{[1
,2
,3
]}

Lingyan Cao ^{[1
,2
,3
]}

Lingjie Peng ^{[1
,2
,3
]}

Xiao Wang ^{[1
,2
,3
]}

Jie Wang ^{[1
,2
,3
]}

Xianzhen Xin ^{[1
,2
,3
]}

Xinquan Jiang ^{[1
,2
,3
]}

机构：

[1] Department of Prosthodontics,Shanghai Ninth People'sHospital,Shanghai Jiao Tong University School of Medicine

[2] College of Stomatology,National Center for Stomatology,National Clinical Research Center for Oral Diseases,Shanghai Jiao Tong University

[3] Shanghai Key Laboratory of Stomatology,Shanghai Engineering Research Center of Advanced Dental Technology and Materials

来源：

Bio-Design and Manufacturing | 2022年 / 5卷 / 02期

基金：

中国国家自然科学基金;

关键词：

D O I：

暂无

中图分类号：

R783.1 [牙科材料学];

学科分类号：

080502 ;

摘要：

Following dental implantation,the characteristic bacterial milieu of the oral cavity may lead to peri-implant inflammation,which can negatively impact osseointegration and cause implant failure.To improve soft tissue sealing around the implant,enhance osseointegration,and improve implant success rates,this paper proposes a composite multifunctional coating(PHG)prepared using gelatin and polydopamine/hydroxyapatite nanoparticles,investigates the effects of this novel coating on cell adhesion,proliferation,antibacterial activity,osteogenic differentiation,and evaluates its immune-related properties.The PHG coating was proved to have satisfactory hydrophilicity and wettability for cell attachment.Furthermore,it improved the expression of adhesion-related genes and proteins in human gingival fibroblasts,indicating its adhesion-promoting effect.Additionally,bone marrow mesenchymal stem cells exhibited strong osteogenic differentiation potential and mineralization on PHG-coated surfaces.Notably,the PHG coating exhibited antibacterial activity against Streptococcus mutans,as well as anti-inflammatory effects,potentially via the regulation of macrophages.Therefore,the proposed PHG coating may promote soft tissue sealing and bone bonding,providing a potential strategy for the surface modification of dental implants.

引用

页码：233 / 248

页数：16

共 26 条

[1] The Effects of Macrophage Phenotype on Osteogenic Differentiation of MSCs in the Presence of Polyethylene Particles [J].

Gao, Qi ;

Rhee, Claire ;

Maruyama, Masahiro ;

Li, Zhong ;

Shen, Huaishuang ;

Zhang, Ning ;

Utsunomiya, Takeshi ;

Huang, Elijah Ejun ;

Yao, Zhenyu ;

Bunnell, Bruce A. ;

Lin, Hang ;

Tuan, Rocky S. ;

Goodman, Stuart B. .

BIOMEDICINES, 2021, 9 (05)

[2] Nerve growth factor-chondroitin sulfate/hydroxyapatite-coating composite implant induces early osseointegration and nerve regeneration of peri-implant tissues in Beagle dogs [J].

Ye, Jun ;

Huang, Bo ;

Gong, Ping .

JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH, 2021, 16 (01)

[3]

Electrochemical Deposition of Nanostructured Hydroxyapatite Coating on Titanium with Enhanced Early Stage Osteogenic Activity and Osseointegration[J] . Minxun Lu,Hongjie Chen,Bo Yuan,Yong Zhou,Li Min,Zhanwen Xiao,Xiangdong Zhu,Chongqi Tu,Xingdong Zhang.International journal of nanomedicine . 2020

[4] Metal Coordination-Mediated Functional Grading and Self-Healing in Mussel Byssus Cuticle [J].

Xu, Quan ;

Xu, Meng ;

Lin, Chun-Yu ;

Zhao, Qiang ;

Zhang, Rui ;

Dong, Xiaoxiao ;

Zhang, Yida ;

Tian, Shouceng ;

Tian, Yu ;

Xia, Zhenhai .

ADVANCED SCIENCE, 2019, 6 (23)

[5] Accentuated osseointegration in osteogenic nanofibrous coated titanium implants [J].

Das, Siddhartha ;

Dholam, Kanchan ;

Gurav, Sandeep ;

Bendale, Kiran ;

Ingle, Arvind ;

Mohanty, Bhabani ;

Chaudhari, Pradip ;

Bellare, Jayesh R. .

SCIENTIFIC REPORTS, 2019, 9 (1)

[6] Synergistic Osteogenesis of Biocompatible Reduced Graphene Oxide with Methyl Vanillate in BMSCs [J].

Jiao, Delong ;

Cao, Lingyan ;

Liu, Yang ;

Wu, Jiannan ;

Zheng, Ao ;

Jiang, Xinquan .

ACS BIOMATERIALS SCIENCE & ENGINEERING, 2019, 5 (04) :1920-1936

[7] Novel Aptamer-Functionalized Nanoparticles Enhances Bone Defect Repair By Improving Stem Cell Recruitment [J].

Wang, Meng ;

Wu, Haibin ;

Li, Qiao ;

Yang, Ying ;

Che, Fengyu ;

Wang, Guoxia ;

Zhang, Liyu .

INTERNATIONAL JOURNAL OF NANOMEDICINE, 2019, 14 :8707-8724

[8] Functionalization of Silk Fibroin Electrospun Scaffolds via BMSC Affinity Peptide Grafting through Oxidative Self-Polymerization of Dopamine for Bone Regeneration [J].

Wu, Jiannan ;

Cao, Lingyan ;

Liu, Yang ;

Zheng, Ao ;

Jiao, Delong ;

Zeng, Deliang ;

Wang, Xiao ;

Kaplan, David L. ;

Jiang, Xinquan .

ACS APPLIED MATERIALS & INTERFACES, 2019, 11 (09) :8878-8895

[9]

Near-infrared light-controllable on-demand antibiotics release using thermo-sensitive hydrogel-based drug reservoir for combating bacterial infection[J] . Ge Gao,Yao-Wen Jiang,Hao-Ran Jia,Fu-Gen Wu.Biomaterials . 2018

[10] MicroRNA-31a-5p from aging BMSCs links bone formation and resorption in the aged bone marrow microenvironment [J].

Xu, Rongyao ;

Shen, Xiang ;

Si, Yameng ;

Fu, Yu ;

Zhu, Weiwen ;

Xiao, Tao ;

Fu, Zongyun ;

Zhang, Ping ;

Cheng, Jie ;

Jiang, Hongbing .

AGING CELL, 2018, 17 (04)

← 1 2 3 →